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James Briscoe is a Senior Group Leader at The Francis Crick Institute in London, where he leads a research group focused on developmental biology and morphogen signaling. He previously held positions at the Medical Research Council's National Institute for Medical Research, which later became part of the Francis Crick Institute. Education: BSc in Microbiology and Virology from the University of Warwick, UK PhD from Imperial Cancer Research Fund/King's College London Postdoctoral training at Columbia University with Thomas Jessell Dr. Briscoe's research focuses on the molecular and cellular mechanisms of graded signaling by morphogens and the role of transcriptional networks in cell fate specification. His laboratory employs a range of experimental and computational techniques using model systems including mouse and chick embryos and embryonic stem cells. His work has significant implications for understanding developmental processes and their relationship to disease. His recent publications demonstrate a continued focus on morphogen gradients, neural tube development, and computational approaches to understanding cell fate decisions. His research increasingly integrates single-cell technologies and computational modeling to unravel the complexities of developmental patterning. Scientific Awards and Honors: EMBO Young Investigator (2001) EMBO Gold Medal (2008) Elected to EMBO (2009) Fellow of the Academy of Medical Sciences (2019) Fellow of the Royal Society (2019) As Editor-in-Chief of the journal Development since 2018, Dr. Briscoe plays a significant role in shaping the field of developmental biology. His leadership extends to mentoring researchers and contributing to scientific policy discussions, as evidenced by his recent publication 'Science under siege: protecting scientific progress in turbulent times.' Dr. Briscoe's laboratory at the Crick Institute is well-equipped with access to advanced facilities including light microscopy, flow cytometry, genomics, and computational resources, enabling a multidisciplinary approach to developmental biology questions.

• Developmental Biology
• Molecular Signaling
• Transcriptional Networks
• +4 more

Calliope Dendrou is an Associate Professor in Clinical Pathology and Inflammation at the Kennedy Institute of Rheumatology (KIR), University of Oxford, leading the Immune Disease Multiomics Laboratory. She previously held a Wellcome & Royal Society Sir Henry Dale Fellowship at the University of Oxford’s Centre for Human Genetics before joining KIR in 2023. Her research focuses on immune disease mechanisms using multiomics approaches, including genomic profiling to identify therapeutic targets across tissues and immune-mediated diseases. She co-leads large-scale projects like the Oxford-J&J Cartography Consortium and the Chan Zuckerberg Initiative’s LEGACY Network, and teaches on the MSc in Genomic Medicine program. Educational Background: BSc (Biology, Imperial College London, 2005; Forbes Memorial Medal Winner); PhD in Infection & Immunity (University of Cambridge, 2010). Postdoctoral training at the Weatherall Institute of Molecular Medicine under Prof. Lars Fugger. Research interests include immunogenetics, cytokine signaling pathways, drug repositioning, and cross-disease pathophysiology. Her work integrates single-cell and spatial transcriptomics to dissect immune-cell interactions in diseases like rheumatoid arthritis, inflammatory bowel disease, and celiac disease. Recent articles highlight her contributions to understanding vaccine adjuvant responses, Th17 cell roles in spondyloarthritis, and immune-epithelial networks in celiac disease. Collaborations emphasize multi-omic data analysis (e.g., Panpipes pipeline) and translational studies toward precision medicine. Awards: Forbes Memorial Medal (BSc), Wellcome & Royal Society Sir Henry Dale Fellowship. Leadership roles include Equality, Diversity, and Inclusion Champion and 'Single-Cell & Spatial Omics for Precision Medicine' Module Lead. Lab & Teams: Immune Disease Multiomics Lab at KIR. Active in collaborative initiatives such as the LEGACY Network, focusing on large-scale immune profiling in ancestrally diverse populations.

• Immunology
• Genomics
• Multiomics Analysis
• +3 more

Silvia Santos is a Group Leader at the Francis Crick Institute, leading the Quantitative Stem Cell Biology Lab since January 2018. Her research focuses on understanding cell decision-making during transitions, specifically cell division and differentiation in early development using human embryonic stem cells. She combines experimental techniques with theoretical approaches, including advanced microscopy, genomics, and computational modeling. Education and Career: PhD in Molecular and Cell Biology from EMBL-Heidelberg (2008), followed by postdoctoral training at Stanford University (2009-2014). She held an MRC Career Development Award at Imperial College London (2014-2017) before joining the Crick. Her work emphasizes interdisciplinary methods to study cellular processes in health and disease. Research Interests: Spatial-temporal control in cell decisions, stem cell differentiation, cell cycle regulation, and modeling embryonic development. She advocates for women in science and mentorship programs for early-career researchers. Key Achievements: Recipient of Marie Curie E-Star, EMBO, and HFSP fellowships. Recognized with the BioModels’ Model of the Year 2023 for contributions to systems biology. Her lab develops models like gastruloids to study embryonic development. Grants and Mentorship: Supported by MRC and other grants. Committed to fostering excellence in training and mentorship, previously chairing mentorship initiatives at Imperial College London. Labs and Teams: Quantitative Stem Cell Biology Lab at the Crick, collaborating with interdisciplinary teams on projects involving proteomics, genomics, and high-throughput screening.

• Developmental Biology
• Cell Biology
• Cell Cycle & Chromosomes
• +3 more

Dr. Gabriele Schweikert is a Senior Lecturer and Principal Investigator with a joint appointment between the Division of Computational Biology in the School of Life Sciences at University of Dundee and Cyber Valley in Tuebingen. Her research focuses on applying machine learning techniques to understand epigenetic mechanisms and molecular processes in living cells. Dr. Schweikert completed her PhD at the Max Planck Institute Tuebingen working with Schoelkopf, Weigel, and Raetsch labs on machine learning for computational gene finding. She subsequently joined Adrian Bird's lab at the Wellcome Trust Center for Cell Biology in Edinburgh, a pioneer in epigenomic research. Prior to her current position, she held prestigious Marie Curie and EMBO Fellowships at the School of Informatics, University of Edinburgh. Her research interests center on using machine learning to decode epigenetic mechanisms that determine cellular identity and function. She investigates how cells with identical DNA can differentiate into specialized cell types through epigenetic regulation, with particular focus on applications in understanding tumorigenesis where epigenetic machinery malfunctions. Her work combines high-throughput epigenomic data with advanced computational approaches to address complex biological questions. Analysis of her recent publications reveals a strong focus on epigenomic data analysis, machine learning applications in biology, and computational approaches to understanding gene regulation. Her work spans from fundamental epigenetic mechanisms to practical applications in disease research, with growing emphasis on individual-specific epigenomic analysis and explainable AI in biomedical contexts. UKRI Future Leaders Fellowship (2020, £1.6 million) Marie Curie Fellowship EMBO Fellowship Dr. Schweikert actively supervises PhD students and has received significant research funding for projects including 'Machine Learning Methods to Re-Annotate Histone Modifications,' 'Unlocking The Alternative Splicing Code,' and 'GPU-Based Machine Learning System For Fundamental Biological Research.' She is involved in multiple interdisciplinary collaborations and frequently presents her work at major conferences including ELLIS Health program retreat, Epigenetics Meetings, and RECOMB workshops. She maintains active research laboratories in both Dundee and Tuebingen, fostering international collaboration between computational biologists, machine learning experts, and experimental biologists to advance our understanding of epigenetic regulation in health and disease.

• Computational Biology
• Machine Learning
• Epigenetics
• +6 more

Laia Becares is a Professor of Social Science and Health at King's College London, part of the School of Global Affairs and the Department of Global Health & Social Medicine. She previously held roles at the University of Sussex (2018-2022) and the University of Manchester (2010-2018), where she maintains an Honorary position. She serves as an Editor of Sociology of Health and Illness and on the Academic Reference Group of the NHS Race and Health Observatory. Her work is funded by organizations such as the Nuffield Foundation and the Health Foundation. Laia holds a PhD in Social Epidemiology from University College London (UCL) and a Master's in Public Health from Boston University School of Public Health. Her research employs an interdisciplinary approach, collaborating with sociologists, psychiatrists, geographers, and demographers to understand how discrimination and marginalization perpetuate social and health inequities. Key areas include racism, homophobia/heterosexism, LGBTQ+ inequalities, and the impact of systemic oppression across life stages. She co-developed the Queerantine Study on pandemic impacts on LGBTQ+ communities and leads the ESRC Centre for Society and Mental Health, fostering student mentorship in health inequality topics. Her scientific awards include ESRC/MRC Postdoctoral Research Fellowship (2010-2012), Hallsworth Research Fellowship (2012-2016), and ESRC Future Research Leader Fellowship (2012-2015). Recent work focuses on ethnic healthcare disparities in multimorbidity and longitudinal studies of racism's effects on health outcomes. Ongoing projects include LGBTQ+ policymaking networks and the GHSM Anti Racism Steering Group, addressing structural inequities in academia and healthcare. Laia’s grants include Nuffield Foundation funding for ethnic inequalities in later life and Health Foundation support for healthcare equity studies. She advocates for integrating lived experiences into research design, particularly through the Evidence for Equality National Survey (EVENS). Her lab affiliations include Queer@King’s and the ESRC Centre for Society and Mental Health, emphasizing collaborative, community-driven approaches.

• Social Epidemiology
• Health Inequalities
• Racism and Health
• +3 more

Yang Luo is a Kennedy Trust Senior Research Fellow in Data Science at the University of Oxford's Kennedy Institute of Rheumatology. His research bridges statistical genomics and computational immunology to unravel genetic contributions to immune-mediated traits, with a focus on the major histocompatibility complex (MHC) region. His work leverages large biobank datasets (UK Biobank, Biobank Japan), gene expression resources (GTEx), and proteomic data to decode molecular mechanisms linking genetic variation to disease risk. Specific interests include tuberculosis genetics, multi-ancestry polygenic risk scores, and single-cell eQTL modeling. Recent publications highlight expertise in HLA association studies, evolutionary immunogenetics, and disease-specific cell state dynamics. Key contributions include constructing a global HLA haplotype panel and developing novel statistical methods for admixed population genetics. Scientific Awards: Kennedy Trust Senior Research Fellow in Data Science His lab integrates computational and experimental approaches to translate genetic findings into clinical applications for immune disorders.

• Statistical Genomics
• Computational Immunology
• Human Genetics
• +2 more

John Diffley is a Principal Group Leader and Associate Research Director at The Francis Crick Institute in London, UK, where he leads research on DNA replication mechanisms. His work focuses on understanding how cells precisely duplicate their DNA during cell division and how errors in this process contribute to cancer development. Diffley obtained his PhD from New York University in 1985 and completed postdoctoral training with Bruce Stillman at Cold Spring Harbor Laboratory until 1990. He established his research group at the Clare Hall Laboratories (originally Imperial Cancer Research Fund, then Cancer Research UK) before moving to The Francis Crick Institute in 2015. His research spans DNA replication initiation, cell cycle control, replication fork checkpoints, and epigenetic inheritance. Diffley's lab has pioneered methods to reconstitute chromatin replication using purified proteins, providing unprecedented insights into chromosome biology. His team combines genetics, cell biology, and biochemistry to study the molecular 'machines' that copy DNA in yeast and human cells. Analysis of Diffley's recent publications reveals a strong focus on structural mechanisms of DNA replication, particularly using cryo-EM to visualize replication machinery. His work examines helicase loading and activation, replication fork stability under stress, and the connection between replication errors and cancer development. The research spans model organisms to human cells, with increasing emphasis on structural approaches in recent years. FRS (Fellow of the Royal Society) FMedSci (Fellow of the Academy of Medical Sciences) Diffley actively mentors a diverse team of postdoctoral researchers and PhD students, investigating various aspects of DNA replication. His lab has received substantial funding to support their work on replication mechanisms, with projects spanning basic biochemical reconstitution to studies of replication errors in cancer contexts. The lab maintains multiple technical platforms including structural biology, biochemistry, and cell biology approaches. His research group operates within The Francis Crick Institute's collaborative environment, utilizing shared facilities for structural biology, microscopy, and genomics to advance understanding of DNA replication mechanisms and their implications for genome stability and disease.

• DNA Replication
• Cell Cycle Control
• Chromosome Biology
• +5 more

Professor Richard Wade-Martins is a leading academic in University of Oxford 's Department of Physiology, Anatomy and Genetics . He directs the Molecular Neurodegeneration Research Laboratory and the Oxford Parkinson’s Disease Centre (OPDC). With degrees from Cambridge (MA) and Oxford (DPhil), he has held prestigious fellowships including Wellcome Trust Research Career Development Fellowship and NIH reviewer roles. His research targets molecular mechanisms in Parkinson’s and Alzheimer’s diseases through iPSC models , transgenic mice , and lysosomal function studies . He pioneered work on SNCA , MAPT , and LRRK2 gene pathways. Current projects focus on gene therapy and mitochondrial dysfunction in neurodegeneration. Key publications (2019–2025) reveal trends in single-cell transcriptomics , calcium channel inhibition , and TFEB/TFE3 lysosome modulation . His awards include Wellcome Trust Fellowships and advisory roles for Parkinson's UK , Alzheimer's Research UK , and EU consortia like StemBANCC and EFACTS . He leads the UK Dementia Platform iPSC Initiative and serves on international boards in Luxembourg and Canada.

• Neurodegenerative Diseases
• Molecular Neuroscience
• Stem Cell Research
• +3 more

Dr. Calum Gabbutt is a Chapman-Schmidt AI in Science Postdoctoral Research Fellow at Imperial College London's Department of Mathematics (Faculty of Natural Sciences) and a Postdoctoral Training Fellow at the Institute of Cancer Research (ICR), London. He holds a PhD in Mathematical Biology from Queen Mary University of London (2017–2021) and an MPhys from the University of Oxford (2013–2017). His research focuses on mathematical and computational methods to understand clonal dynamics and cancer evolution, particularly leveraging genomic and lineage tracing data. He develops Bayesian inference models to analyze evolutionary processes in cancer, aiming to improve clinical outcomes through precision medicine. Key areas include genetic barcoding, methylation-based molecular clocks, and phylogenetic reconstruction of tumor evolution. Recent work spans large-scale genomic analyses of cancer evolution, computational tools like PISCA-box for somatic chromosomal alterations, and studies on phenotypic plasticity in metastasis and therapy resistance. His research integrates AI-driven approaches to decode cancer heterogeneity and temporal dynamics in human tissues. Collaborations span institutions like the ICR and Queen Mary University of London, emphasizing interdisciplinary methods at the intersection of mathematics, computational biology, and oncology.

• Mathematical Biology
• Cancer Evolution
• Computational Biology
• +4 more

Dr. Justin Gerlach is a Fellow at Peterhouse College and an Academic Associate at the University Museum of Zoology, University of Cambridge. He specializes in broad-spectrum ecology, integrating conservation biology, evolutionary studies, and biodiversity analysis with a focus on island ecosystems in the Indian and Pacific Oceans. His research has pioneered invertebrate reintroduction programs and revealed groundbreaking insights into giant tortoise behavior. Education: DPhil in Zoology from Oxford University Current projects: Biodiversity assessment across Cambridge colleges, Partula snail reintroduction, tortoise aging studies Research interests center on preventing species extinction through conservation, studying species interactions, and evolutionary dynamics. Key initiatives include saving island invertebrates, investigating tortoise predation, and environmental DNA applications for ecosystem reconstruction. Recent publications highlight island conservation challenges, evolutionary patterns, and ecological innovations. Themes include biodiversity preservation, species reintroduction, and interdisciplinary approaches to conservation biology.

• Conservation Biology
• Ecology
• Evolutionary Biology
• +4 more

Professor John Bone is a Personal Chair in the Department of Sociology at the University of Aberdeen, School of Social Science. His work bridges sociology, political economy, neuroscience, and environmental policy, with a strong focus on just transitions, social well-being, and the biosocial impacts of contemporary capitalism. PhD in Sociology, University of Aberdeen (2004) MA Hons in Sociology, University of Aberdeen (1998) John Bone’s research centers on political economy, social and biosocial theory, and energy justice. He has developed an original biosocial framework known as the 'social map' to analyze how human biological capacities interact with social structures, affecting identity, health, and cohesion. His recent book, The Great Decline (2024), critiques the psychological and societal harms of hyper-mediated, neoliberal societies and warns of unpreparedness for AI and climate change. His empirical work examines energy transitions, particularly in Aberdeen, where he leads the Aberdeen Just Transitions Lab. His recent publications span interdisciplinary themes in just transition, climate governance, and social theory. Key trends include the development of metrics for equitable energy transitions, stakeholder engagement in nuclear decommissioning, and the role of deliberative democracy in climate assemblies. His work frequently addresses regional policy, social inequality, and the psychological impacts of economic precarity. Philip Abrams Memorial Prize 2007 (Joint Winner, Best First Book in Sociology) John Bone has supervised numerous PhD students, including David Magee, Karen Lumsden, and Lorna Watson. He has been a co-applicant on major grants such as UKRI’s Just-Systems project (£5.7M) and NIHR’s Aberdeen Health Determinants Research Collaborative (£1.3M). His leadership roles include Head of Department (2013–2019), Social Science Enterprise Champion, and Coordinator of the Aberdeen Just Transitions Lab. He has also served as Chair of the British Sociological Association (2018–2021). He leads the Aberdeen Just Transitions Lab and collaborates with the Aberdeen Health Determinants Research Centre. His research teams engage with policymakers, NGOs, and community groups, including Aberdeen City Council, NHS Grampian, and the Just Transition Commission, to ensure research has real-world impact on policy and social equity.

• Political Economy
• Social Theory
• Biosocial Theory
• +8 more

Tim Lewens is Professor of Philosophy of Science and Head of the Department of History and Philosophy of Science at the University of Cambridge, currently on leave for the 2024/25 academic year. His career bridges philosophy, biology, and bioethics with significant institutional roles including Deputy Director of CRASSH (2014-2017) and Council Member of the Nuffield Council on Bioethics (2009-2015). His research focuses on philosophy of biology, evolutionary theory, and bioethics, with particular expertise in human nature debates, extended evolutionary synthesis, and medical ethics. Key contributions include critical analyses of mitochondrial replacement therapy ethics, genome editing implications, and conceptual challenges in cultural evolution. His work consistently addresses interdisciplinary tensions between biological determinism and social constructivism. Analysis of his 15 most recent publications reveals dominant themes in evolutionary philosophy (40%), bioethics (35%), and conceptual foundations of science (25%). Notable trends include re-examining Paleyan design arguments in modern biology, ethical frameworks for emerging biotechnologies, and interdisciplinary approaches to human nature that challenge essentialist perspectives. Lewens has secured major research funding including an ERC grant for 'A Science of Human Nature?' (2011-2016) and Templeton Foundation funding for 'Putting the Extended Evolutionary Synthesis to the Test' (2016-2019). His policy impact is evident through contributions to Nuffield Council reports on mitochondrial DNA disorders (2012) and human body donation (2011), demonstrating applied philosophical engagement with contemporary medical ethics.

• Philosophy of Biology
• Philosophy of Science
• Bioethics
• +3 more

Professor Nicholas Shea is a philosopher affiliated with the Institute of Philosophy at the University of London. He specializes in interdisciplinary research at the intersection of philosophy of mind, psychology, cognitive neuroscience, and artificial intelligence. His work spans topics like representational content, metacognition, consciousness, and agency across biological and computational systems. Education : BA in Mathematics, MA and PhD in Philosophy (Birkbeck and King’s College London), postdoctoral research at Oxford University. His research integrates empirical findings from cognitive science with philosophical analysis. Recent projects include the ERC-funded Metacognition of Concepts (2016–2021) and collaborations with Oxford University and City University, London. Key publications examine dual-process cognition, conceptual content, and non-genetic inheritance. His work has been cited over 1,073 times, reflecting his influence in philosophy of science and mind. Scientific Awards : European Research Council Consolidator Grant (2016) AHRC Fellowship ('Meaning for the Brain, Meaning for the Person') He has supervised 6 research students and led projects like Mental Health and Justice (Wellcome Trust 2017–2022) and TeleoLogic (2016–2018). Collaborations include work with Chris Frith and institutions across neuroscience and philosophy.

• Philosophy of Mind
• Philosophy of Psychology
• Cognitive Neuroscience
• +12 more

Professor Sir Peter Barnes is a leading figure in respiratory science at Imperial College London's National Heart and Lung Institute (NHLI) . As Professor of Thoracic Medicine , his work focuses on Asthma, COPD, and cellular senescence in lung disease , with over four decades of contributions to understanding inflammatory pathways and therapeutic innovations. Research Interests Mechanisms of chronic airway inflammation in Asthma and COPD Cellular senescence in lung aging and disease progression MicroRNA transfer via extracellular vesicles in COPD pathogenesis Targeted drug delivery for respiratory conditions Global health implications of lung disease Recent Publications highlight trends in: MicroRNA regulation of senescence and inflammation Extracellular vesicle dynamics in lung disease Biologics and corticosteroid efficacy in respiratory conditions Environmental factors influencing COPD and asthma Scientific Recognition Knighthood (2023) for services to respiratory science Fellow of the Royal Society (FRS) and Academy of Medical Sciences (FMedSci) Collaborative Leadership at NHLI has mentored numerous postdocs and researchers. His work intersects with global initiatives like GOLD (Global Initiative for COPD) , influencing clinical guidelines and public health policy.

• Respiratory Science
• Asthma
• COPD
• +5 more

Hajime Murakami is an Advanced Research Fellow at the University of Aberdeen's School of Medicine, Medical Sciences and Nutrition, where he conducts cutting-edge research on meiotic recombination mechanisms. His work focuses on understanding how cells manage the complex process of DNA double-strand break formation and repair during meiosis, with implications for human fertility and chromosome disorders. Dr. Murakami's research interests center on the molecular mechanisms of meiotic recombination, particularly the role of DNA double-strand breaks (DSBs) in chromosome segregation. His laboratory investigates how proteins like Hop1 and Red1 function as 'manager proteins' that direct the DNA 'scissors' to appropriate chromosomal locations, ensuring proper recombination while preventing errors that could lead to miscarriage or congenital syndromes. His work primarily uses yeast as a model system, which shares fundamental meiotic mechanisms with humans. Analysis of Dr. Murakami's publication record reveals a consistent focus on the molecular regulation of meiotic recombination across his career. His research has progressively uncovered sophisticated control mechanisms that ensure accurate chromosome segregation, with particular emphasis on how cells manage DNA break formation across chromosomes of different sizes. His work spans fundamental molecular mechanisms to potential clinical applications in reproductive medicine. Dr. Murakami has received significant recognition for his work, most notably a Medical Research Council (MRC) Career Development Award, which supports his ongoing research into the molecular basis of meiotic recombination. As an active researcher accepting PhD students in Biomedical Sciences, Dr. Murakami continues to advance our understanding of fundamental genetic processes that underlie human reproductive health. His laboratory at the Institute of Medical Sciences on Foresterhill Campus employs yeast genetics and molecular biology approaches to investigate the critical processes that ensure proper chromosome segregation during gamete formation.

• Genetics
• Genomics
• Molecular Biology
• +3 more