Find Academic Supervisors

• Inflammasome Biology
• Chemical Biology
• Protease Biochemistry
• +2 more

Daniel Bachovchin is Professor of Molecular Pharmacology at Memorial Sloan Kettering Cancer Center (MSKCC), where he leads a research laboratory focused on inflammasome biology and chemical immunology. His work bridges chemical biology and innate immunity, with primary affiliations through the Tri-Institutional Training Program in Chemical Biology and collaborations across MSKCC's molecular pharmacology research division. Research interests center on the molecular mechanisms of NLRP1 and CARD8 inflammasome activation, particularly how proteases like DPP8/9 regulate these pathways. His laboratory employs chemical biology approaches to develop selective inhibitors and probes, revealing how cytosolic peptide accumulation, redox stress, and proteolytic events trigger pyroptosis. Recent work demonstrates CARD8's role as a sensor for proteasome dysfunction and NLRP1's response to reductive stress. Analysis of recent publications (2021-2024) shows a clear trajectory from structural characterization of inflammasome components toward therapeutic applications. Key themes include: Elucidation of NLRP1/CARD8 activation by redox changes and proteolytic events Development of M24B aminopeptidase inhibitors as selective inflammasome activators Discovery of DPP9's dual roles in inflammasome repression through both enzymatic and scaffolding functions The Bachovchin Lab actively trains graduate students from the Tri-Institutional Training Program in Chemical Biology, Gerstner Sloan Kettering Graduate Program, and Weill Cornell Medical College Pharmacology program. Postdoctoral fellows receive competitive compensation through MSKCC's subsidized housing program while investigating innate immunity mechanisms. Current research leverages chemical tools to explore inflammasome biology in cancer contexts, particularly examining how immune activation pathways could be harnessed for leukemia treatment as suggested by earlier work on DPP8/9 inhibitors. Experimental approaches combine high-throughput screening, structural biology, and chemical proteomics to dissect inflammasome regulation. The laboratory maintains strong collaborative ties with structural biologists (e.g., Hao Wu's lab) and microbiome researchers, reflecting the interdisciplinary nature of modern immunology research.

• Computer Science
• Genetics
• Evolutionary Biology
• +3 more

Tony Capra is an Assistant Professor of Computer Science at the Vanderbilt University School of Engineering , where he investigates intersections of computational methods and biomedical research. His work leverages advanced informatics to explore genetic and evolutionary questions with direct clinical relevance. Education: Ph.D. and M.A. in Computer Science from Princeton University; B.A. in Computer Science and Mathematics from Columbia University Dr. Capra's research program focuses on developing computational frameworks to address challenges in human genetics, evolutionary biology, and biomedical applications. His laboratory specializes in: Biomedical machine learning Evolutionary genomics Structural variant interpretation Electronic health record analysis Comparative 3D genome modeling Population-scale data integration His recent publications demonstrate increasing emphasis on cross-species evolutionary comparisons, structural biology applications, and clinical translation of genomic insights. Key methodologies involve machine learning at biobank scales and functional annotation of noncoding variation. Current affiliations include the Department of Computer Science and Biomedical Engineering at Vanderbilt, with research teams working at the interface of computational biology and clinical data science. Collaborative efforts span human genetics, primate genomics, and precision medicine initiatives.

Anna SchwendemanView profile

Professor

• Synthetic HDL Nanomedicines
• Atherosclerosis Treatment
• Alzheimer's Disease
• +7 more

Anna Schwendeman is a Professor of Pharmaceutical Sciences at the University of Michigan College of Pharmacy. Her research focuses on synthetic high-density lipoprotein (HDL) nanomedicines for treating atherosclerosis and other diseases through cholesterol transport and targeted delivery. She has extensive experience in pharmaceutical industry (Cerenis Therapeutics, Pfizer, Esperion Therapeutics) and has translated multiple HDL therapies to Phase II clinical trials. Research Interests: Rational design of HDL nanomedicines Phospholipid composition optimization Apolipoprotein A-I mimic peptides Therapeutic applications for Alzheimer’s, sepsis, lupus, and diabetic nephropathy Targeted delivery to SR-BI-expressing tumors Regulatory science for complex parenteral products Scientific Awards: American Heart Association Fellow (2023) Controlled Release Society Fellow (2023) American Heart Association Scientist Development Grant (2013) Presidential Fellowship, The Ohio State University (2000) Biomedical Innovation Shark Tank Winner (2015) Grants & Collaborations: Research supported by the American Heart Association and U.S. Food and Drug Administration. Collaborative projects include HDL utility in Alzheimer’s disease, sepsis, and glioblastoma treatment. She also develops science-based regulations for testing nanoparticles and recombinant proteins.

Frank LE FOLLView profile

Professor

• Marine Immunology
• Bivalve Hemocyte Function
• Environmental Toxicology
• +3 more

Frank LE FOLL serves as Professor and Deputy Director of SEBIO (Environmental Stress and BIOmonitoring of aquatic environments) at the University of Le Havre Normandy, France. His research focuses on bivalve immune defense systems, particularly hemocyte function in Mytilus edulis and related species, investigating cellular responses to pathogens, chemical contaminants, and environmental stressors. His primary research interests include Marine Immunology , Bivalve Hemocyte Function , and Environmental Toxicology , with emphasis on inflammation mechanisms, phagocytic capacity, and oxidative burst responses. Using advanced cell biology techniques—including primary culture models, confocal imaging, flow cytometry, and time-lapse microscopy—his work addresses critical issues in aquatic pathobiology, vibrio infections, and mussel farm mortalities. Current projects examine immunotoxic impacts of anthropogenic pollutants and develop immunomarkers for water body biomonitoring. Recent publications (2023-2025) reveal strong thematic continuity in marine immunotoxicology , with increasing focus on multi-stressor interactions (temperature, contaminants, pathogens) and field application of cellular biomarkers. Key trends include standardization of hemocyte motility as an inflammation marker, comparative studies across sentinel species ( Mytilus , Dreissena , Palaemon ), and development of integrated monitoring protocols for coastal and freshwater systems. As Deputy Director of SEBIO, he oversees technical platforms including Cell Biology-Cytometry and Molecular Biology-Microbiology units. His laboratory operates at the University of Le Havre's main campus (Lebon site), utilizing specialized facilities for aquatic organism experimentation and environmental biomonitoring.

Renato Emanuel Felix BotoView profile

Associate Professor

• Organic Chemistry
• Medicinal Chemistry
• Photodynamic Therapy
• +4 more

Renato Emanuel Félix Boto is an Associate Professor at the Department of Chemistry, University of Beira Interior (UBI), Portugal. He is also a vice-coordinator of the Biopharmaceuticals and Biomaterials Research Group (BB) within the Health Sciences Research Centre (CICS-UBI). His academic career spans over 25 years, with teaching responsibilities in Organic Chemistry. Graduated in Analytical Chemistry (1993) from University of Aveiro PhD in Chemistry (2007) from University of Beira Interior Provas de Aptidão Pedagógica e Capacidade Científica (1999) equivalent to MSc Dr. Boto's research focuses on synthesizing functional cyanine dyes for biomedical applications, including photodynamic therapy (PDT) , fluorescent probes , and chromatographic ligands for protein/DNA separation. His work bridges organic synthesis with therapeutic development and analytical chemistry applications. Recent trends in his publications emphasize indolenine-based squaraine dyes for cancer treatment, antifungal agents , and albumin detection probes . He has contributed to optimizing synthetic methodologies for barbiturate-coupled dyes and benzisoxazole derivatives . He has supervised 6 MSc students and co-supervised 3 others, while contributing to 5 research projects including: UID/Multi/00709/2019 (completed) CENTRO-45-2018-10 (ongoing) CENTRO-01-0145-FEDER-000013 (completed) Dr. Boto co-authored over 30 peer-reviewed articles with 259 citations and participated in numerous national/international scientific meetings.

Tapas K. MannaView profile

Associate Professor

• Cell Biology
• Biochemistry
• Molecular Biology
• +3 more

Dr. Tapas K. Manna is an Associate Professor at the School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram . He holds a Ph.D. in Biochemistry (2004) from Jadavpur University and an M.Sc. in Chemistry (1997) from Calcutta University. His research focuses on kinetochore and centrosome biology , chromosome segregation , and mitotic spindle regulation in mammalian cells. Ph.D. in Biochemistry, 2004 (Jadavpur University, Bose Institute) M.Sc. in Chemistry, 1997 (Calcutta University) Manna's work explores the molecular mechanisms governing kinetochore-microtubule interactions , centrosome biogenesis , and mitotic checkpoint activation . His research combines biochemical , cell biological , biophysical , and imaging techniques to identify therapeutic targets for cancer and chromosomal disorders . Over the last decade, his publications have emphasized centriole duplication , ubiquitin signaling , microtubule dynamics , and spindle pole organization . Scientific Awards : S. Ramachandran National Bioscience Award (2019) Manna has received extramural funding from DST, CSIR, DAE, and DBT. His lab has mentored numerous students, including Ph.D. candidates and project fellows , many of whom have pursued postdoctoral work or Ph.D. programs internationally. His team investigates centrosome signaling pathways and mitotic regulation , with recent studies on CKAP5 and FBXW7 roles in chromosome stability .

Jeremie KalfonView profile

Researcher

• Computational Biology
• Bioinformatics
• Machine Learning in Genomics
• +5 more

Jeremie Kalfon is a researcher at the Pasteur Institute in Paris, France, specializing in computational biology and gene regulatory network inference. His work focuses on leveraging machine learning and large-scale single-cell data analysis to unravel complex biological systems, particularly in cancer and immune diseases. Notably, he is a key contributor to the development of scPRINT , a transformer-based model for gene network prediction, batch correction, and denoising in genomics. Primary Affiliation : Pasteur Institute (Institut Pasteur) Research Themes : Computational biology, bioinformatics, leukemia genomics, single-cell RNA-seq modeling Research Trends : Kalfon’s publications demonstrate expertise in: Designing AI-driven tools for gene network inference Uncovering transcriptional plasticity in leukemia Mapping synthetic lethal interactions in cancers Decoding codon usage patterns and metabolic vulnerabilities Grant Support : ANR-16-CONV-0005 (French National Research Agency) European Research Council H2020 grant #101115618 Collaborative Networks : He collaborates with interdisciplinary teams at Pasteur Institute and contributes to educational workshops on AI in life sciences, reflecting his commitment to training the next generation of computational biologists.

Elena Vikentievna RomanovaView profile

Academic

• Bioanalytical Chemistry
• Mass Spectrometry
• Peptidomics
• +6 more

Elena Vikentievna Romanova serves as Research Assistant Professor in the Department of Chemistry at the University of Illinois at Urbana-Champaign, with significant affiliations in the College of Liberal Arts & Sciences, Neuroscience Program, and Beckman Institute for Advanced Science and Technology. She plays a key role in the Neuroproteomics & Neurometabolomics Center on Cell-Cell Signaling, a NIDA-funded center renewed through 2029 that provides proteomics, metabolomics, and bioinformatics technologies to neuroscience researchers worldwide. Romanova earned her undergraduate degree in Biology from Belarusian State University and completed her PhD in Chemistry at the University of Illinois under Jonathan Sweedler in 2005. Following her doctoral studies, she joined the newly established Neuroproteomics & Neurometabolomics Center to develop technological solutions for investigating neurochemical changes related to drug abuse and addiction. She joined the Department of Chemistry faculty as Research Assistant Professor in January 2019. Her research program centers on bioanalytical chemistry with emphasis on microanalysis, mass spectrometry, and liquid separation techniques for characterizing biomolecules in nervous and neuroendocrine systems. Specific approaches include high throughput peptidomics, single cell and tissue chemical profiling, differential quantitative assessment of neurochemical changes, and mass spectrometry imaging. Her work aims to elucidate molecular mechanisms underlying physiological responses in animal models relevant to fundamental and translational neuroscience research. Analysis of her recent publications reveals consistent focus on advancing peptidomics and single-cell analysis methodologies. Her research spans neurochemistry, analytical chemistry, and addiction studies, with particular expertise in characterizing signaling molecules ranging from small molecules like nitric oxide to large, heavily post-translationally modified proteins exceeding 100 kDa. Her work has significant implications for understanding addiction mechanisms and developing therapeutic interventions. Romanova coordinates multidisciplinary collaborative projects within the Center's framework, which includes Sampling & Separation, Molecular Profiling & Characterization, and Bioinformatics cores. Notable collaborations include work with Jim Zaijie Wang studying hemorphins in sickle cell disease and pain mechanisms. Her laboratory utilizes cutting-edge technologies including: High throughput peptidomics Direct single cell chemical profiling Differential neurochemical assessment Mass spectrometry imaging Advanced bioinformatics tools

Qiuguo FuView profile

Researcher

• Environmental Analytical Chemistry
• Emerging Organic Contaminants
• Transformation and Toxicokinetic Processes
• +7 more

Dr. Qiuguo Fu is a Group Leader and Senior Scientist at the Helmholtz-Centre for Environmental Research – UFZ , Department of Analytical Chemistry, since 2022. His career includes roles as Scientist (2019-2021) and Post-doctoral Researcher (2016-2019) at Eawag – Swiss Federal Institute of Aquatic Science and Technology, Department of Environmental Chemistry, and PhD studies at the University of California, Riverside (2014-2016) and Zhejiang University, China (2010-2013). Education : PhD study, Environmental Sciences, University of California, Riverside (2014–2016) PhD student, Environmental Chemistry, Zhejiang University (2010–2013) Dr. Fu’s research focuses on innovative analytical method development for emerging organic chemicals like PFAS, PMT, and pesticides, identification and quantification of contaminants and their transformation products, and transformation and toxicokinetic processes of organic pollutants. His work spans environmental monitoring, toxicokinetic modeling, and risk assessment, with projects such as PrePoPMGW (PM substances in groundwater), PERFORCE3 (PFAS analysis), SmartManure (circular economy in agriculture), and MibiTox (microbiome-pesticide interactions). His recent publications emphasize high-resolution mass spectrometry for contaminant screening, biotransformation in aquatic species , and PFAS detection in biota . He contributes to the NORMAN prioritisation scheme for EU chemical strategies and explores species-specific plasma protein binding of PFAS. Despite no explicit awards mentioned, his work aligns with EU environmental policies and practical solutions for agricultural sustainability . Dr. Fu leads the Trace Organic Analysis research group and engages in interdisciplinary projects like nanoINHALE and SafePol, addressing microplastics, PFAS, and pollinator health. His teaching and team seek students in life sciences for theses and internships, focusing on interdisciplinary research .

Francesco TombolaView profile

Professor

• Voltage-Gated Ion Channels
• Molecular Dynamics Simulations
• Membrane Biophysics
• +3 more

Francesco Tombola, PhD, is a Professor in the Department of Physiology & Biophysics at the University of California, Irvine (UCI) School of Medicine. He also serves as Associate Dean for Graduate & Postdoctoral Studies. Research focuses on voltage-gated proton channels (Hv1) and their inhibition via molecular dynamics simulations Key areas: Membrane biophysics, ion channel pharmacology, and computational modeling of channel blockers Active grants include NIH R01 GM098973 for Hv1 channel research His work elucidates Hv1's role in pH homeostasis, phagocyte respiratory bursts, and disease pathologies like inflammatory conditions and cancer. Recent studies examine thermodynamics of channel blocker permeation and allosteric modulation mechanisms. Selected publications highlight collaborations on: 2024 PNAS study on Hv1 proton conduction selectivity 2023 J Neurochem analysis of microglial reprogramming via Hv1 antagonism 2021/2020 structural models of Hv1 from molecular simulations 2014-2015 investigations of channel inhibition mechanisms

Victor Bolanos-GarciaView profile

Senior Lecturer

• Cell Division Regulation
• Structural Biology
• Cancer Research
• +3 more

Dr. Victor Bolanos-Garcia is a Senior Lecturer in Clinical Biochemistry at Oxford Brookes University and Principal Investigator leading the Mechanisms of Regulation of Cell Division Group . With a PhD from the University of Cambridge and postdoctoral training at the MRC Laboratory of Molecular Biology, his research focuses on structural and biochemical mechanisms governing cell division regulation, particularly in cancer contexts. Research Interests include: Structural biology of mitotic checkpoint proteins (BUB1, BUBR1, Mps1) Molecular interactions in DNA damage repair systems Development of nanomaterials for cancer therapeutics Protein biochemistry for drug target validation Recent Publications address APC/C inhibitors for breast cancer, graphene-based delivery systems, and Mps1 kinase dynamics. His work has been instrumental in defining protein-protein interfaces for therapeutic intervention. Professional Memberships : Fellow of the Higher Education Academy (FHEA-UK) Member of Cancer Research UK Oxford Centre International Evaluator for Mexico's CONACyT Students Supervised : PhD: Natalie L. Curtis, Maria Kapanidou, Dave Gervais MSc: Multiple unnamed students Co-supervised: Samuel Connelly, Teresa Minguez Vinas, Brittany Almond External Co-supervision: University of Cambridge (Qian Wu, Takashi Ochi, Deepti Gupta, Ann Ling), University of Rennes (Lionel Chieze)

Tony BradshawView profile

Lecturer

• Biochemistry
• Molecular Biology
• Analytical Chemistry
• +2 more

Dr Tony Bradshaw is a Lecturer in Biochemistry at the School of Biological and Medical Sciences , Oxford Brookes University. His work spans analytical chemistry methodologies, molecular biology, and toxicology, with a focus on pharmaceutical analysis, DNA damage mechanisms, and enzyme activity studies. Research Interests Education Publications Research Trends: Dr Bradshaw's publications demonstrate expertise in: Development of chromatographic methods for pharmaceutical analysis Mechanistic studies of DNA damage and repair Investigation of enzyme activity changes during chemical exposure Structural analysis of organic compounds Interferon production modulation

• Computational Biology
• Bioinformatics
• Multi-Omics Integration
• +6 more

Ana Rita Grosso is an Assistant Professor at the Department of Life Sciences , NOVA School of Science and Technology (FCT-NOVA) , NOVA University Lisbon , and heads the Computational Multi-Omics Group . Since 2018 she has built an independent research program focused on leveraging multi-omics to decode cancer and other pathologies. Education PhD in Biomedical Sciences, Faculty of Medicine, University of Lisbon (iMM/FMUL, 2010) MSc in Bioinformatics, Faculty of Sciences, University of Lisbon (FCUL-IGC, 2006) Licenciatura (BSc) in Biology, Faculty of Sciences, University of Lisbon (FCUL, 2002) Research Interests Grosso’s work sits at the intersection of computational biology , bioinformatics , and biomedicine . She integrates large-scale genomics, transcriptomics, and epigenomics datasets to uncover molecular events underlying tumor evolution, metastasis, and tissue-specific splicing regulation, aiming to translate findings into biomarkers and therapeutic targets. Scientific Awards & Grants 3 × Pfizer Awards for Basic Research 10 competitive project grants (4 as PI/Co-PI, 6 as team member) 4 salary/stipend grants (PhD, Post-Doc, and 2 research contracts) EMBO Workshop Grant Advising & Training She has supervised 4 PostDocs , 3 PhD students , 3 MSc fellows , 10 MSc students , 7 BSc students , and numerous short-term trainees, while teaching Genomics and Computational Biology courses at FCT-NOVA. Laboratory & Teams She founded and leads the Computational Multi-Omics Lab at FCT-NOVA, an interdisciplinary team applying systems-biology approaches to cancer and biomedical questions.

James KronstadView profile

Professor

• Fungal pathogenesis
• Medical mycology
• Plant-microbe interactions
• +7 more

James Kronstad is a Professor in the Department of Microbiology and Immunology at the University of British Columbia , based at the Michael Smith Laboratories . A leading figure in fungal biology, he investigates the molecular mechanisms underlying pathogenesis, morphogenesis, and host–microbe interactions in both plant and human fungal pathogens. Education & Academic Background While explicit degree details are not provided, his long-standing professorship and leadership in genomics and molecular genetics indicate extensive training in microbiology and fungal biology. Research Focus Kronstad’s lab employs functional and structural genomics to dissect how fungi adapt to, and exploit, their hosts. Major themes include: Fungal pathogenesis : Understanding how Cryptococcus neoformans and C. gattii cause life-threatening infections, especially in immunocompromised individuals. Plant-microbe interactions : Elucidating how Ustilago maydis and U. hordei infect maize and barley, respectively, leading to smut diseases. Iron homeostasis & signaling : Deciphering transcriptional networks (Cir1, HapX) that regulate iron acquisition and virulence. cAMP/PKA signaling : Investigating how this pathway controls morphological transitions and pathogenicity across basidiomycetes. Comparative genomics : Building physical maps and reference genomes to enable comparative studies of pathogenic fungi. Recent Publications & Trends Between 2024-2025, the lab has published extensively on redox regulation, polyphosphate metabolism, iron acquisition, and novel antifungal targets, reflecting a pivot toward translational applications in antifungal therapy and vaccine development. Scientific Awards & Recognition Burroughs Wellcome Fund Scholar Award in Molecular Pathogenic Mycology Canadian Institute for Advanced Research (CIFAR) Fellowship, Fungal Kingdom: Threats & Opportunities Graduate Training & Mentorship Kronstad currently supervises multiple PhD candidates and post-doctoral fellows, including Sara Vujakovic, Braydon Black, Elise Bedford, Djihane Damoo, Xianya (Sabrina) Qu, and Kabir Bhalla. A long list of former trainees (over 40 names) attests to his extensive mentorship record. Funding & Collaborations Research is funded by the Natural Sciences and Engineering Research Council of Canada , Canadian Institutes of Health Research , National Institute of Allergy and Infectious Diseases (NIH) , BC Lung Association , and Genome Canada/Genome BC . The lab actively partners with the Michael Smith Genome Sciences Centre for large-scale sequencing projects and welcomes interdisciplinary collaborations. Laboratory & Facilities The Kronstad Lab is housed within the state-of-the-art Michael Smith Laboratories at UBC, offering cutting-edge facilities for genomics, proteomics, molecular genetics, and animal infection models.

• Immunology
• Molecular Biology
• Virology
• +3 more

Professor William Cushley is a faculty member at the University of Glasgow within the College of Medical, Veterinary and Life Sciences under the Institute of Molecular Biosciences. He has maintained a leadership role as Assistant Vice-Principal for International (External Relations) and has been actively involved in research related to immunology and molecular biology. Role: Assistant Vice-Principal (External Relations) Research Focus: Integrin signaling, CD23 protein interactions, Epstein-Barr virus pathogenesis His research explores integrin-mediated cell signaling in pre-B cell leukemia, focusing on RGD-independent interactions with CD23, and investigates Epstein-Barr virus oncogenesis mechanisms. Key themes include inflammation regulation, immune disease modulation, and cancer cell survival pathways. Recent publications highlight integrin signaling (avb5) in lymphoid malignancies, EBV's role in lymphomagenesis, and cytokine receptor interactions. These span immunology, biochemistry, and virology disciplines. Grants include funding from Blood Cancer UK and Leukaemia Research Fund for integrin signaling in ALL. He serves on advisory boards for Medical Research Scotland and Babraham Institute committees.