James C. LoView profile
Associate Professor
James C. Lo, M.D., Ph.D., is the Rohr Family Clinical Scholar and Associate Professor of Medicine at Weill Cornell Medical College . As a physician-scientist, he directs a basic research laboratory investigating the molecular basis of cardiometabolic diseases. 2023 : Rohr Family Clinical Scholar 2023 : Associate Professor of Medicine, Weill Cornell Medical College 2021 : Assistant Professor of Medicine, Weill Cornell Medical College Education: 2006 - M.D., University of Chicago Pritzker School of Medicine 2004 - Ph.D., University of Chicago 1998 - B.S., University of Chicago Dr. Lo's research focuses on molecular mechanisms of metabolic diseases with emphasis on: Cardiovascular biology in diabetes and obesity Adipose tissue function and thermogenesis Pancreatic islet physiology in metabolic stress Inter-organ communication networks Novel therapeutic targets for diabetes Cardiac complications in metabolic disorders Complement system in endocrine regulation His lab employs single-cell RNA-seq , genetic models , and multi-omics approaches to study: β cell subpopulations in diabetes Complement receptor signaling Adipose-liver-heart cross-talk Extracellular vesicle-mediated dysfunction Sex-dependent metabolic regulation Scientific Contributions: First to identify adipsin's role in β cell protection Discovered complement system's role in islet function Defined adipose tissue as SARS-CoV-2 target Elucidated mechanisms of obesity-induced arrhythmias Developed cross-species models of metabolic stress Research Funding: Currently holds 8 major grants as Principal Investigator or Key Personnel, including: $2.1M - NIH/NHLBI Mechanisms of Obesity-induced Atrial Fibrillation (2025-2028) $2.8M - NIH/NIDDK NAD+ Metabolism in β Cell Dysfunction (2025-2030) $1.5M - AHA Obesity-Driven Atrial Fibrillation (2024-2027) $1.2M - AHA Zebrafish Heart Regeneration (2023-2026) His laboratory team at the Belfer Research Building (New York, NY) includes post-doctoral fellows, Ph.D. students, medical students, and research technicians working in a collaborative environment.







