Ziru Li

Ziru Li is a Faculty Scientist I at the MaineHealth Institute for Research (MHIR) and an affiliated faculty member of the Graduate School of Biomedical Science and Engineering (GSBSE) at the University of Maine. She is actively involved in cutting-edge research on metabolism, bone biology, and bariatric surgery outcomes.

Education:

• Ph.D. in Clinical Medicine, Peking University, 2014
• Postdoctoral Training, University of Michigan-Ann Arbor

Dr. Li's research focuses on the biological mechanisms of obesity and metabolic regulation, with a particular interest in the gut-bone axis and bone marrow adipose tissue. Her work investigates how bariatric surgeries such as vertical sleeve gastrectomy influence bone density and marrow composition, uncovering key roles for signaling molecules like G-CSF and sclerostin. She employs molecular, genetic, and physiological approaches in mouse models to dissect metabolic pathways involving mTOR, Wnt/β-catenin, and adipocyte lipolysis.

Her recent publications reveal a strong trend in understanding how adipose tissues—particularly bone marrow adipocytes—function as active endocrine and metabolic organs. These studies span disciplines including endocrinology, cell biology, and metabolic surgery, highlighting her interdisciplinary approach. Key themes include adipocyte-bone crosstalk, energy homeostasis during caloric deficit, and therapeutic targeting of bone loss post-surgery.

Dr. Li has not been mentioned with any scientific awards in the provided text.

She mentors graduate students through her affiliation with the GSBSE program, contributing to the training of future biomedical scientists. Her research is supported by collaborative grants, particularly with leading institutions such as the University of Michigan and MaineHealth. She is based at the MHIR facility in Orono, Maine, and maintains active collaborations across the GSBSE network, including the University of New England and The Jackson Laboratory.

Dr. Li leads a research laboratory focused on metabolic regulation and bone health, working within a statewide consortium that promotes transdisciplinary innovation in biomedical science.