Yuwei Shi

Yuwei Shi is a Researcher at the Department of Clinical Genetics, Erasmus University Medical Center, specializing in the genetic basis of neurodevelopmental and neurological disorders through advanced genomic methodologies.

Shi's research portfolio encompasses:

• Neurogenetics of intellectual disability and neurodevelopmental disorders
• High-throughput sequencing applications (Exome, Genome, RNA)
• X-chromosome inactivation mechanisms
• Autosomal recessive inheritance patterns
• Gene deletion events in cytogenetic contexts
• Hereditary spastic paraplegia pathogenesis

Recent publications demonstrate integration of multi-omics approaches with functional validation, particularly in expanding phenotypic spectra of rare genetic disorders and identifying novel therapeutic targets like statin-based interventions for spastic paraplegia. The work consistently leverages international collaborations across clinical genetics networks to bridge molecular findings with patient phenotypes.