Yan Ping Yu

Yan Ping Yu, MD, PhD, is an Associate Professor in the Division of Experimental Pathology at the University of Pittsburgh and serves as Associate Director of the High Throughput Genome Center. Her research program investigates genomic instabilities in human cancers, with emphasis on prostate cancer mechanisms involving fusion transcripts, RNA epigenetics, and tumor suppressor pathways.

Research interests focus on:

• Characterization of cancer-specific fusion genes in prostate, lung, and liver tumors
• Epigenetic regulation of RNA in prostate carcinogenesis
• Therapeutic targeting of GPx3-mediated apoptosis pathways
• High-throughput genomic analysis of formalin-fixed clinical specimens

Her recent publications (2021-2024) demonstrate:

• Machine learning applications for prostate cancer prognosis using fusion transcripts
• COVID-19's impact on hematological systems
• AVITI sequencing chemistry optimizations
• Methylation patterns predictive of cancer recurrence

Laboratory leadership includes directing the High Throughput Genome Center, which supports advanced genomic analyses across multiple cancer research programs.