About
YAN Li is a Research Fellow in the Department of Microbiology at Monash University. Their work focuses on immunology, cancer biology, and molecular mechanisms underlying tumor progression, with an emphasis on genetic engineering tools and RNA sequencing technologies. Key research areas include tumor suppressor pathways, T cell biology, and the interplay between inflammation and cancer.
YAN Li has contributed to groundbreaking studies on CRISPR-based genetic screens, p53 pathway dysregulation in cancer, and the role of transcription factors in immune cell differentiation. They have developed influential bioinformatics tools like featureCounts and Rsubread, which are widely used in RNA-seq data analysis.
Recent work highlights novel insights into IL-6-mediated cancer vulnerability, ER stress in anti-tumor drug mechanisms, and systems immunology approaches to dengue fever pathogenesis. Their interdisciplinary research bridges basic science and translational applications in oncology and immunotherapy.
Publications span top journals in cancer research, immunology, and computational biology, with a focus on mechanistic studies of tumor microenvironment, immune evasion, and epigenetic regulation. Ongoing efforts include refining CRISPR technologies and exploring therapeutic targets in myeloma and colorectal cancer.
