Xiaochen He

Xiaochen He serves as an Instructor in the Department of Physiology & Biophysics at the University of Mississippi Medical Center's School of Medicine, where he focuses on cardiovascular research and teaching within this foundational medical science department.

His research program centers on the intersection of cardiac pathophysiology and immunometabolism, with core interests including:

• Mechanisms of immune-mediated cardiac inflammation in heart failure
• Role of T cell subsets (Th17, γδ T, CD8+) in pressure overload models
• Molecular regulation by IL-12 family cytokines and metabolic enzymes (TIGAR, SIRT3)
• Endothelial dysfunction in cardiac hypertrophy and failure progression
• Therapeutic interventions targeting inflammatory pathways

Analysis of Dr. He's recent publications (2022-2025) reveals a concentrated research trajectory investigating how specific immune pathways drive heart failure progression. His work consistently employs genetic mouse models to demonstrate that IL-12β inhibition, TIGAR deficiency, and selenium supplementation attenuate cardiac inflammation and dysfunction, while CD8+ T cell metabolic reprogramming exacerbates disease. Key discoveries include GPR174's role in Th17 differentiation and NK1.1 signaling's contribution to cardiopulmonary inflammation, establishing critical immune-metabolic axes in heart failure pathogenesis.

No scientific awards were documented in the available profile information.

Current departmental records indicate no graduate students are formally listed under Dr. He's mentorship, and no research grants are specified in the public profile.

Details regarding laboratory infrastructure, research teams, or collaborative networks were not provided in the available institutional documentation.