About
Douglas Tilley, PhD, is a Professor and Assistant Dean at the Lewis Katz School of Medicine at Temple University. He holds appointments in the Department of Cardiovascular Sciences and is affiliated with the Aging + Cardiovascular Discovery Center and the Lemole Center for Integrated Lymphatics and Vascular Research. His research focuses on GPCR signaling in cardiac and immune systems, particularly in the context of heart failure and post-injury remodeling.
Dr. Tilley's research interests center on molecular mechanisms of cardiac dysfunction and immune regulation. His work investigates how G protein-coupled receptors such as β2-adrenergic receptors and EGFR regulate cardiac contractility, inflammation, and fibrotic remodeling. Key projects include understanding the dual roles of EGFR in hypertrophy and contractile homeostasis, the immunomodulatory effects of β2AR on leukocytes after cardiac injury, and the role of immune cells in cardiorenal syndrome progression. These studies aim to identify novel therapeutic targets for heart failure and related multi-organ pathologies.
His research bridges pharmacology, immunology, and cardiovascular physiology. Though no publications are listed in the provided text, the described projects indicate a strong focus on signal transduction pathways, receptor crosstalk, and organ-system interactions in chronic disease. This work contributes to precision therapeutic strategies in cardiovascular medicine.
- American Society for Pharmacology and Experimental Therapeutics
- American Heart Association
- International Society for Heart Research, American Section
Dr. Tilley mentors within a multidisciplinary research environment and leads projects supported by institutional and potentially external funding, though specific grants are not detailed. His role as Assistant Dean suggests leadership in academic programming or research administration. He is actively involved in advancing cardiovascular discovery through team-based science in integrated research centers.
He is a key member of the Aging + Cardiovascular Discovery Center and the Lemole Center for Integrated Lymphatics and Vascular Research, where he collaborates on vascular biology, lymphatic function, and systemic inflammation in cardiovascular disease. These centers provide a collaborative platform for translational research aimed at improving outcomes in aging and chronic cardiovascular conditions.
Research fields
