William Sheffield

William Sheffield is a Professor in the Department of Pathology and Molecular Medicine at McMaster University, with expertise in Biochemistry, Hematology, and Molecular Medicine. His research focuses on blood coagulation, serpin family proteins, and transfusion medicine.

• Ph.D., McGill University (1983)
• Post-doctoral Fellowship in Hematology, McMaster University (1989-1992)

Key research areas include:

• Blood Coagulation: Mechanisms of thrombin inhibition, factor IX/XI dynamics, and hemostatic regulation
• Serpin Engineering: Protein structure modification for enhanced specificity in antithrombotic therapy
• Transfusion Products: Quality assessment of plasma, cryoprecipitate, and freeze-dried plasma
• Red Blood Cell Biology: Membrane rigidity, storage lesions, and stress-induced cell death

Recent publications highlight trends in albumin fusion proteins for prolonged therapeutic effects, phage display screening of protease inhibitors, and animal models for traumatic coagulopathy. His work has been referenced in 29 patents and clinical guidelines.

Teaching activities include instructing Inquiry III: Advanced Inquiry in Health Sciences (HTHSCI 3E03) since 2018. Current affiliations span multiple Canadian Blood Services research initiatives and international collaborations in transfusion science.