Colin Kretz

Colin Kretz is an Associate Professor in the Department of Medicine at McMaster University within the Faculty of Medicine. His research focuses on the molecular mechanisms of blood coagulation, thrombosis, and hemostasis, with particular expertise in ADAMTS13 enzyme function and von Willebrand Factor biology.

Dr. Kretz's research interests center on understanding the molecular mechanisms underlying thrombotic disorders, particularly focusing on the ADAMTS13-von Willebrand Factor axis. His work encompasses protein engineering, enzyme kinetics, and the investigation of coagulation disorders in various clinical contexts including sepsis, trauma, and aging. He employs advanced techniques such as deep mutational scanning, proteomics, and biosensor development to elucidate the structure-function relationships of key hemostatic proteins. Recent research has expanded into historical analysis of blood products and their modern applications in trauma care.

Analysis of Dr. Kretz's recent publications (2021-2025) reveals a strong focus on ADAMTS13 enzyme regulation, von Willebrand Factor interactions, and novel diagnostic approaches for coagulation monitoring. His work spans basic molecular mechanisms to clinical applications, with increasing attention to sepsis-related coagulopathies and innovative blood product development. The research demonstrates interdisciplinary approaches combining hematology, molecular biology, proteomics, and clinical medicine to address critical questions in thrombosis and hemostasis.

Dr. Kretz serves as an instructor for the course 'Vascular Diseases, Haemostasis and Thrombosis I' (MEDSCI 732) at McMaster University, teaching in 2022, 2024, and 2025. While specific grant information isn't detailed in the provided text, his extensive publication record across high-impact hematology journals suggests successful research funding. The Interdisciplinary Research Fund (IRF) at McMaster has supported related work, though direct attribution to Dr. Kretz requires further verification.

His research appears to involve collaborations with McMaster's Thrombosis and Atherosclerosis Research Institute (TaARI), though specific laboratory details aren't explicitly mentioned in the provided text. The work spans multiple model systems including murine models, zebrafish, and human clinical samples, suggesting a comprehensive approach to studying hemostatic disorders across translational research spectrum.