William Rigby

William Rigby is a Professor of Medicine and Microbiology & Immunology at the Geisel School of Medicine, Dartmouth College. His research focuses on translational immunology in

• Rheumatoid Arthritis (RA)
• Cystic Fibrosis (CF)
• Chronic Lymphocytic Leukemia (CLL)
• Total Knee Replacement (TKR) outcomes

through clinical biorepositories and molecular investigations.

Key research areas include

• Autoimmunity to BPI protein in CF patients
• Complement C4 gene copy number variation in RA
• Novel mechanisms of therapeutic monoclonal antibodies (rituximab/obinutuzumab) involving trogocytosis
• Biomarker discovery for predicting treatment outcomes

Article analysis reveals a focus on innovative immunotherapeutic mechanisms in both autoimmune and malignant conditions, with particular attention to

• Phagocytic cell interactions
• Antibody-mediated B cell modulation
• Complement pathway dysregulation
• Precision medicine in orthopedic surgery

Dr. Rigby's lab collaborates with clinical teams to develop translational frameworks connecting molecular immunology with patient care outcomes.