Sarosh R. Irani

Sarosh R. Irani is a Professor of Neurology and Neuroscience at Mayo Clinic, Jacksonville, Florida, and an Adjunct Professor of Neurology at the University of Southern Denmark. He is a leading neurologist and scientist specializing in autoimmune neurological diseases, with a focus on autoimmune encephalitis, neuromyelitis optica, and antibody-mediated disorders. Previously, he served as Professor of Autoimmune Neurology at the University of Oxford.

• Education: D.Phil. in Clinical Neurology, University of Oxford; B.M., B.Ch. in Medicine, University of Oxford
• Professional Training: Clinical residency in neurology (UK), Fulbright Fellowship in multiple sclerosis and autoimmune neurology (UCSF, USA)
• Leadership: Founder of Oxford Autoimmune Neurology Clinic; leads a research group at Mayo Clinic

Dr. Irani's research spans both clinical and laboratory domains. His work has been pivotal in identifying and characterizing autoimmune encephalitis subtypes, particularly those associated with LGI1 and CASPR2 antibodies. He has made landmark contributions to understanding B cell dynamics, monoclonal antibody pathogenicity, and immunotherapeutic strategies. His team has published over 200 scientific papers and discovered key biomarkers and clinical phenotypes.

Analysis of his recent publications reveals a strong focus on autoimmune encephalitis mechanisms, B cell immunology, patient-reported outcomes, neuroimaging, and translational models. His work integrates genetics, immunology, and clinical neurology to advance diagnostics and therapies.

His scientific awards include the Cozzarelli Prize (2024), Clinical Science Prize from the International Society of Neuroimmunology (2021), Graham Bull Prize (2019), and the Wellcome Intermediate Fellowship (2014), among many others.

Dr. Irani has supervised over 50 international clinicians and scientists and mentored multiple students and fellows to independent research careers. He is actively involved in clinical trials, patient advocacy (e.g., Encephalitis Society, Autoimmune Encephalitis Alliance), and international collaborations. His lab investigates B cell receptor sequencing, monoclonal antibody cloning, and cross-compartmental immune dynamics in neurological autoimmunity.