Václav Profant

Václav Profant is an Assistant Professor at the Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague. His research focuses on Vibrational and Chiroptical Spectroscopy, particularly using Raman Optical Activity (ROA), Circular Dichroism (CD), and quantum mechanical calculations to study biomolecular structure and dynamics.

• Born: November 24, 1983, Strakonice
• Workplace: Room F186, Institute of Physics, Ke Karlovu 5, Prague 2
• Email: vaclav.profant@matfyz.cuni.cz, profant@karlov.mff.cuni.cz
• Academic Affiliation: Charles University since 2008

Research Interests include:

• Structure and dynamics of proteins and carbohydrates
• Quantum mechanical modeling of molecular properties
• Vibrational Circular Dichroism (VCD)
• Fluorescence anisotropy decay measurements
• Microcalorimetry (DSC) for thermodynamic characterization

Recent Publications span:

• 2024: ROA analysis of guanine quadruplexes
• 2024: Polymorphic DNA-protein interactions in c-Fos promoter
• 2023: Pesticide conformational studies via SERS and DFT
• 2022: Metal ion effects on histidine complexes
• 2020: Antimicrobial peptide structure with disulfide bridges

Scientific Recognition:

• 2013: Promising Young Researcher Award at CD 2013 (Nashville)
• 2008: Second Prize in Spectroscopic Thesis Competition

Academic Contributions:

• Teaching courses in quantum theory, biophysics, and chiroptical spectroscopy since 2008
• Supervising 12+ students (Bc., Mgr., PhD) across vibrational spectroscopy projects
• Leading and participating in grants studying DNA-transcription factor interactions and peptide folding