Troy Harkness

Troy Harkness is an Adjunct Professor in the Department of Medicine, Division of Geriatric Medicine, at the University of Alberta's Faculty of Medicine and Dentistry. His research leverages the budding yeast as a model organism to investigate molecular and genetic mechanisms of aging, with translational implications for human aging, cancer, and premature aging disorders such as Hutchinson-Gilford Progeria Syndrome (HGPS).

His research interests include:

• Molecular mechanisms of longevity and aging
• Role of the Anaphase Promoting Complex (APC) in genomic stability and lifespan
• Translational models of cancer drug resistance
• Yeast-based screening for aging and disease pathways
• Development of premature aging models using human Progerin

Dr. Harkness's recent publications reveal a strong focus on APC activation as a regulator of stress resistance, lifespan, and cancer cell resensitization. His work spans yeast genetics, human cancer cell models, and in vivo mouse studies, demonstrating a multidisciplinary approach. Key themes include ubiquitin ligase function, kinome and SILAC analyses, and high-throughput aging assays.

His scientific contributions have been published in journals such as Cancers, Aging Cell, Aging, and eLife. While no specific awards are listed, his work has significant therapeutic implications for aging and cancer.

Dr. Harkness mentors several graduate students and a research associate, indicating an active lab environment focused on training and discovery. His team is currently exploring APC activators, molecular networks in aging, and novel therapeutics for progeria and drug-resistant cancers.

His laboratory is located in the Heritage Medical Research Centre, and he collaborates extensively within the aging and cancer research communities.