Stuart McQuarrie

Stuart McQuarrie is a researcher at the School of Biology, University of St Andrews, specializing in molecular biology and CRISPR systems. His work contributes to the UN Sustainable Development Goals through advancements in genetic defense mechanisms.

• Primary Affiliation: School of Biology, University of St Andrews
• Research Focus: CRISPR-based bacterial immunity, nucleases, cyclic nucleotide signaling

Research Interests: McQuarrie’s research explores the structural and enzymatic properties of CRISPR-associated proteins, particularly their roles in anti-phage defense and cyclic nucleotide signaling. Current projects include mechanistic studies of membrane protein interactions in CRISPR systems, ribonuclease activation dynamics, and structural analysis of nuclease-effector complexes.

• Key themes: Bacterial immunity, RNA cleavage, protein conformational changes
• Recent publications focus on CRISPR-Cas systems, restriction-modification synergism, and type III defense pathways

Dataset Contributions: Structural data for proteins like Can2 and Csx3/Crn3 in complex with cyclic tetra-adenylate (cA4) have been deposited in the Protein Data Bank (PDB IDs 7BDV, 6YUD).