Tianmin Fu

Tianmin Fu is an Associate Professor in the Department of Pathology at UMass Chan Medical School, with additional appointments in Biochemistry and Molecular Biotechnology, RNA Therapeutics Institute, and multiple graduate programs including Biophysical Chemical and Computational Biology. His research focuses on structural and molecular mechanisms of biological processes, particularly in anti-phage defense systems, RNA-guided DNA targeting, and membrane protein function.

• UMass Chan Medical School - Pathology
• T.H. Chan School of Medicine - Biochemistry and Molecular Biotechnology
• RNA Therapeutics Institute
• Morningside Graduate School of Biomedical Sciences

Research Trends (2018-2025): Fu’s work spans structural biology, molecular mechanisms of immune signaling, and anti-viral/anti-phage defense systems. Key contributions include cryo-EM studies on TRPM2 channels, V-ATPase regulation, inflammasome activation, and CRISPR-Cas interplay between nuclease and protease activities. His recent publications emphasize anti-phage defense architectures (e.g., HerA-DUF, Gabija) and DNA-guided DNA targeting by DdmDE.