Stefan Remy

Prof. Dr. Stefan Remy serves as a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Magdeburg, where he investigates disease-related alterations in synaptic signal processing during behavior, with emphasis on neurodegenerative pathologies like Alzheimer's disease.

His research spans neural circuit dynamics, dendritic signal processing, and behavioral neuroscience, utilizing:

• In vivo whole-cell patch-clamp recordings and STED microscopy to study neuronal hyperexcitability in Alzheimer's models
• Optogenetic and electrophysiological approaches to dissect subcortical modulation of memory circuits (e.g., locus coeruleus and medial septum)
• Two-photon Ca²⁺ imaging and biophysical modeling for dendritic encoding of spatial behavior

His work establishes critical links between structural degeneration, network dysfunction, and memory impairment.

Remy's laboratory develops integrated methodologies combining behavioral analysis, cellular imaging, and computational prediction of neuronal output from synaptic inputs, advancing therapeutic strategies for early network hyperexcitability in dementia.