About
Dr. Slava Ziegler is a Project Group Leader at the Department of Chemical Biology, Max Planck Institute of Molecular Physiology in Dortmund, Germany. His research focuses on identifying bioactive small molecules and elucidating their molecular targets and mechanisms of action through chemical proteomics, biochemical, biophysical and genetic approaches.
- Academic Appointments: Project Group Leader, Chemical Biology (2016-present)
- Education: Diploma in Biochemistry (Ruhr University Bochum), PhD in Biochemistry (MPI & Ruhr University), Postdoc at University Hospital Düsseldorf
Research Interests center on:
- Phenotypic screening using Cell Painting assays
- Target identification for bioactive compounds
- Proteome and lipidome profiling
- Developmental signaling pathway inhibition
- Glucose transporter and glutaminase targeting
- Chemical genetics in cancer metabolism
Notable Contributions include developing high-throughput screening workflows, discovering novel Hedgehog and TRPC inhibitors, and creating chemical probes for:
- Dihydroorotate Dehydrogenase
- RHOGDI
- PI4KIIIß
- IDO1
- TAF1 Bromodomain
- 5-Lipoxygenase
Collaborations with researchers across Europe and Japan have yielded significant insights into:
- Autophagy regulation
- Lysosomal membrane repair
- Microtubule destabilization
- Proteasome inhibition
- Neutrophil extracellular traps
- Embryonic stem cell reprogramming
Contact: slava.ziegler@mpi-dortmund.mpg.de | +49 231 133-2424
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