About
Dr. Mathew Martin is a researcher at Newcastle University, focusing on structural biology and drug discovery for cancer therapies. His work primarily involves crystallographic fragment screening, kinase inhibitor design, and molecular interaction analysis.
His research interests include:
- Kinase Inhibition: Targeting CDK, ERK5, and EGFR with covalent and reversible inhibitors.
- Structural Biology: Utilizing X-ray crystallography to map protein-ligand interactions and validate drug targets.
- Fragment-Based Drug Discovery: Developing NUDELs and FragLites for efficient hit generation in academic cancer research.
Recent publications highlight his contributions to understanding drug resistance mechanisms, optimizing pharmacokinetics, and designing novel inhibitors with scaffold diversity. His collaborations span structural biology, chemical synthesis, and proteomic analysis.
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