About
Amy Heptinstall is a researcher at Newcastle University specializing in cancer therapy development through medicinal chemistry approaches. She collaborates extensively in cross-disciplinary teams focusing on novel drug targets and mechanisms.
- Key Research Areas:
- Bromodomain and kinase inhibition
- Covalent/fragment-based drug design
- Cancer signaling pathways (NF-κB, ERK5, CDK)
- Protein interaction modulation
- Chemical biology of oncology targets
- Translational pharmacology
Her publications from 2018-2022 demonstrate expertise in developing selective inhibitors for cancer-related proteins, with a focus on improving druglike properties and targeting unique cysteine residues. Recent work explores interactions between bromodomains BRD4/ATAD2 and ligands using innovative probe technologies.
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