Simone Frey

Dr. Simone Frey is a researcher in the Department of Systems Biology and Bioinformatics at the Faculty of Computer Science and Electrical Engineering, University of Rostock. Her work focuses on mathematical modeling of biological systems, particularly signal transduction pathways.

Her educational background includes:

• PhD in Systems Biology from University of Rostock (2006-2011)
• Research internship at Biophotonics Group, University of Gothenburg, Sweden (2009)
• Diplom Biomathematik from University of Greifswald (2000-2005)

Dr. Frey's research primarily centers on the mathematical modeling of signal transduction pathways, with a specific focus on the Snf1/AMPK pathway in Saccharomyces cerevisiae (baker's yeast). Her work aims to understand the regulation mechanisms of this pathway through mathematical modeling, addressing questions about kinase and phosphatase regulation. She has investigated how malfunctions in these processes can lead to diseases like type 2 diabetes, with potential implications for identifying drug targets. Her research combines theoretical modeling with experimental data, often collaborating with experimental biologists to validate her models.

Analysis of Dr. Frey's publications reveals a consistent focus on quantitative approaches to understanding biological signaling pathways. Her work spans mathematical modeling techniques, analysis of phosphorylation cascades, and specific applications to the SNF1/AMPK pathway. She has developed methods for analyzing nuclear intensity dynamics, characterizing properties of signal transduction pathways, and unraveling design principles in multi-stage phosphorylation systems.

Dr. Frey has supervised PhD students from 2006 to 2011 and has collaborated with researchers from institutions including the University of Gothenburg. Her research has been supported by various funding sources including the Deutsche Forschungsgemeinschaft (DFG) and the Sixth Framework Programme.