Siddhesh Aras

Siddhesh Aras, MBBS, PhD is an Assistant Professor at the Center for Molecular Medicine and Genetics within Wayne State University School of Medicine. He investigates mitochondrial regulation in pathophysiological contexts including neurodegeneration, cancers, viral infections, and genetic diseases, with a focus on the bi-organellar protein MNRR1/CHCHD2.

• Education: MBBS (University of Mumbai, 2001), PhD (LSU Health Sciences Center, 2009), Postdoc (Wayne State University, 2014)
• Current appointments: Assistant Professor of Molecular Medicine and Genetics

His research interests span oxidative phosphorylation, mitochondrial-nuclear retrograde signaling, and transcriptional regulation of mitochondrial proteins. He employs genetic, molecular, pharmacological, and biochemical approaches to study MNRR1's role in cellular metabolism across pathologies.

Recent publication trends highlight MNRR1's involvement in:

• MELAS syndrome pathophysiology
• Breast and ovarian cancer progression
• Preeclampsia and preterm labor mechanisms
• Viral infection metabolic reprogramming
• Drug target validation via nitazoxanide