Brian Edwards

Brian Edwards is a Professor in the Department of Biochemistry at Wayne State University. His research focuses on elucidating protein structure-function relationships using X-ray crystallography, with key projects in pyrimidine biosynthesis and cytochrome c regulation of mitochondrial processes.

• Ph.D. in Physical Chemistry, Harvard University (1975)
• B.Sc. in Chemistry (Honors Program), University of British Columbia (1969)

Research highlights include:

• Structural studies of pyrimidine biosynthesis enzymes as drug targets for cancer and pathogens
• Investigations into cytochrome c phosphorylation's role in apoptosis and oxidative phosphorylation

His recent publications emphasize:

• Crystallographic analysis of enzyme complexes in thermophilic bacteria
• Molecular dynamics simulations of post-translational modifications in cytochrome c

Collaborations with Dr. Maik Hüttemann in the Center for Molecular Medicine and Genetics extend his work on mitochondrial regulation. Edwards' lab contributes protein structural data to translational research in metabolic disorders and antibiotic development.