Siavash Vahidi

Dr. Siavash Vahidi is an Assistant Professor in the Department of Molecular and Cellular Biology at the University of Guelph. His research focuses on understanding the structure, function, and dynamics of large biomolecular machines, particularly those involved in protein degradation in pathogens like Mycobacterium tuberculosis. He employs advanced techniques such as mass spectrometry (H/D exchange, native MS) and high-field NMR spectroscopy to study these systems. His lab is actively recruiting students and postdocs, emphasizing a commitment to diversity and training in cutting-edge methodologies.

Education:

• BSc in Chemistry, National University of Iran, Tehran
• PhD in Chemistry and Biochemistry, University of Western Ontario
• CIHR Postdoctoral Fellowship, University of Toronto & The Hospital for Sick Children

Research: Key interests include the M. tuberculosis proteasome system, ClpP proteases in human mitochondria, and the role of allostery in substrate selection. The lab’s integrative approach combines structural biology with biochemical and computational methods, aiming to identify novel drug targets for tuberculosis and other diseases.

Awards:

• Paul de Mayo Award for Best PhD Thesis

Lab & Training: The Vahidi Lab emphasizes interdisciplinary training, offering expertise in mass spectrometry, NMR, and computational tools (e.g., Python, Linux). Supported by grants and collaborations, the lab fosters an inclusive environment with a strong focus on mentorship.

Lab Resources:

• Website: Vahidi Lab
• Twitter: @VahidiLab