Sebastian Zanner

Sebastian Zanner is a Researcher in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, specializing in the intersection of bone biology and metabolic disease. His work primarily investigates osteocyte function within cortical bone microstructure under diabetic conditions, with emphasis on vascular complications.

His research program centers on osteocyte biology and bone metabolism in diabetes, utilizing micro-computed tomography to analyze skeletal microstructure. Key interests include diabetic microangiopathy's impact on bone quality, functional genomics of metabolic bone disorders, and the pathophysiological links between vascular health and skeletal integrity in type 2 diabetes.

Zanner's 2023 publication in JBMR Plus establishes a novel association between microvascular disease severity and enlarged osteocyte lacunae in cortical bone of type 2 diabetes patients. This work pioneers the field of 'bone diabetology,' revealing how vascular complications directly alter bone cellular microenvironments, with implications for diabetic fracture risk assessment.

He operates within the Functional Genomic Studies and Metabolism research group, which employs genomic and metabolomic approaches to dissect molecular mechanisms in metabolic diseases, with particular focus on bone-vascular interactions in diabetes pathogenesis.