Sarah McClelland

Sarah McClelland is a Professor focusing on cancer cell biology and genomics, leading a research group dedicated to understanding chromosomal instability in cancer. Her work explores molecular mechanisms driving numerical and structural chromosome aberrations, leveraging molecular and cellular biology techniques alongside single-cell genomics.

• Research Focus: Chromosomal instability, cancer evolution, replication stress, DNA repair, and therapeutic sensitivities.
• Major Funding: CRUK Programme Foundation Award (2025-2031), Medical Research Council Multimodal Award (2022-2025), CRUK RadNet (2021-2024), BBSRC (2021-2024), and Astra Zeneca Collaborative Grant (2020-2022).

Scientific Recognition:
• MDPI Cancers Young Cancer Investigator of the Year (2018).

Her team investigates how oncogene activation and radiotherapy modalities impact genomic stability, aiming to develop DNA repair profiles to optimize cancer treatments. Publications highlight replication stress, CIN, and tumor-specific vulnerabilities.