Samie Jaffrey

Samie Jaffrey, MD, PhD, is the Greenberg-Starr Professor and Professor of Pharmacology at Weill Cornell Medical College. His research focuses on RNA modifications, chemical biology, and imaging techniques. He earned his MD and PhD from Johns Hopkins University and a BS from MIT.

Research Interests: Dr. Jaffrey’s lab explores RNA modifications like m6A and their roles in gene regulation. They develop tools such as fluorogenic RNA aptamers (e.g., Spinach, Broccoli) for live-cell imaging and RNA therapeutics. Their work spans chemical biology, molecular pharmacology, and translational applications in cancer and neuroscience.

Key Themes in Articles: Recent studies highlight m6A’s role in mRNA degradation, viral-host interactions, and epitranscriptomic profiling. His lab also advances methods for RNA imaging and synthetic biology-based therapies.

Grants & Collaborations: He leads NIH-funded projects on epitranscriptomics, cancer biology, and RNA-based technologies. External collaborations include roles in startups like Gotham Therapeutics and Lucerna, Inc.