Richard Bryce

Dr. Richard Bryce is a Reader in Biomedicinal Chemistry at the University of Manchester's Division of Pharmacy and Optometry, within the Faculty of Biology, Medicine and Health. He leads the Computational Biophysics and Drug Design group, focusing on developing computational models to enhance drug design processes through collaborations with chemists, biochemists, and biologists.

Education: BSc in Chemistry from the University of St Andrews (1995), PhD in Computational Chemistry from the University of Manchester (1998). Notable fellowships include the Ramsay Memorial Fellowship (2000-2001) and Robert Lincoln MacNeil Scholarship (1992-1993). His research is supported by EPSRC, Wellcome Trust, MRC, BBSRC, and the Royal Society.

Research Interests: Computational methods for structure-based drug design, carbohydrate energetics/dynamics, molecular simulation, and hybrid QM/MM modeling. Key projects include the AMBER parameter database maintenance and studies on glycan recognition, NLRP3 inflammasome inhibition, and NQO2 enzyme targeting.

Publications: Over 130 peer-reviewed articles (2024 highlights include NLRP3 inhibitors, machine learning potentials, and aggregation modeling). Recent trends focus on integrating AI into drug design, exploring carbohydrate-ligand interactions, and developing anti-inflammatory therapeutics.

Awards: Fellow of the Royal Society of Chemistry (FRSC), former Chair of the Molecular Graphics and Modelling Society.

Grants & Advising: Supervises 20+ PhD/MPhil students and postdocs. Current grants include projects on inflammasome modulation and QSAR-driven drug discovery.

Labs/Teams: Maintains the AMBER parameter database and collaborates internationally on biomolecular simulations and drug development.