Patrik Rorsman

Patrik Rorsman is a Professor of Diabetic Medicine at the University of Oxford, affiliated with Harris Manchester College and the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM). His research focuses on pancreatic islet physiology, particularly the regulation of insulin and glucagon secretion in health and diabetes. He leads a multidisciplinary group studying cellular mechanisms underlying hormone secretion, including metabolic signaling, ion channel function, and intercellular communication within islets.

Key research interests include α-cell and δ-cell function, electrical coupling between islet cells, and the pathophysiological defects in diabetes. Notable contributions include discoveries on glucagon regulation by AVP, nicotinic signaling, and somatostatin receptor antagonists. His team employs advanced electrophysiology, imaging, and stem cell models to explore therapeutic targets for diabetes.

• Awards: Fellow of the Royal Society (FRS) and Fellow of the Academy of Medical Sciences (FMedSci).
• Grants/Funding: Supported by Wellcome Trust, Diabetes UK, JDRF, and MRC.
• Collaborations: Prof Frances Ashcroft, Prof Antony Galione, Prof Bernard Thorens.

Current projects include investigating α-cell heterogeneity, optogenetic control of δ-cells, and clinical trials (e.g., LEGEND-A study). The Rorsman Group also trains PhD candidates and postdoctoral researchers, emphasizing translational research to improve diabetes treatment.