Patrick SENET

Patrick SENET is a Professor of Condensed Matter Physics and Molecular Biophysics at the University of Burgundy (Dijon, France) since 2001. He leads research in theoretical and computational approaches to protein dynamics, nanopore technology, and density functional theory.

• Affiliated with the Nanosciences Department at the Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB).
• Scientific director of the university's computational center (CCuB) since 2016.
• Former leader of the 'Physics Applied to Proteins' research group (2007-2021).

Research Focus

• Protein Folding & Dynamics: Investigates conformational changes, misfolding, and aggregation mechanisms using molecular dynamics and free-energy landscape analysis.
• Nanopore Technology: Develops 2D MoS2 solid-state nanopores for protein sequencing and biomolecule detection.
• Density Functional Theory: Applies conceptual DFT to study reactivity, polarizability, and electronic responses in molecular systems.
• Complex Systems: Utilizes Monte Carlo simulations and graph theory to model nanomaterials and biological processes.

Publications Trends

Recent work focuses on:

• 2D nanopore applications for protein sequencing (2022-2025).
• Statistical analysis of protein folding/unfolding dynamics (2020-2024).
• Computational modeling of glutathione transferases and their biological roles (2018-2023).
• Integration of machine learning in nanopore-based detection systems (2022).