Nicholas Ingolia

Nicholas Ingolia is an Associate Professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. His research focuses on understanding post-transcriptional regulation of gene expression, particularly mRNA translation and stability. He leads the Ingolia Lab, which develops high-throughput techniques like ribosome profiling and APEX-Seq to study translational control mechanisms. Key contributions include characterizing RNA-binding proteins, ribosome rescue pathways, and the role of alternate translation initiation sites.

Education and affiliations are not explicitly detailed, but his work spans molecular biology, biochemistry, and genetics. Recent advancements include CRISPRi-based functional genomics (CiBER-seq) and studies on calcium-dependent protein interactions. The lab collaborates widely, including with Helen Bateup and Ruixuan Gao, and supports graduate students and postdocs in MCB, Computational Biology, and Biophysics programs.

Research interests emphasize translating fundamental discoveries into tools for studying cellular processes. Notable techniques include improved ribosome profiling protocols and proximity labeling for RNA-protein complex analysis. The lab’s work has been published in Nature, Molecular Cell, and Science, among others.