Neal Rosen

Neal Rosen is a Professor of Medicine at Weill Cornell Medical College since 2000. His research focuses on oncogenic signaling pathways, particularly in RAS, BRAF, MEK, and ERK mechanisms, with applications in targeted cancer therapies and drug resistance.

• Education:
  • M.D., Albert Einstein College of Medicine (1979)
  • Ph.D., Yeshiva University (1979)
  • A.B., Columbia University (1971)

Rosen's work explores molecular mechanisms of cancer progression, including:

• BRAF and KRAS mutant tumors
• PTEN and PI3K pathway interactions
• MEK/ERK signaling dynamics
• Heat shock protein 90 (HSP90) as a therapeutic target
• Drug resistance in HER2-positive cancers

His recent publications (2021-2024) highlight:

• Novel combination therapies for RAS-mutant cancers
• Mechanisms of BRAF fusion actionability
• Tumor-agnostic genomic approaches
• Immunomodulatory strategies in solid tumors

Neal Rosen's research integrates molecular biology, pharmacology, and clinical applications to address therapeutic resistance in melanoma, lung cancer, and breast malignancies.