Michael Keogh

Dr. Michael Keogh is a Researcher at Newcastle University, contributing to neurogenetic and mitochondrial disease research. His work focuses on genetic mechanisms underlying neurodegenerative diseases, mitochondrial dysfunction, and brain iron accumulation. He has collaborated extensively with experts in neurology and genetics, publishing widely on topics such as Alzheimer's disease, Lewy body dementia, and genetic variants linked to neurological disorders.

His research interests include understanding the role of genetic mutations (e.g., PLCG2, STXBP1, SCP2) in disease etiology, mitochondrial DNA variations, and the molecular pathways driving neurodegeneration. Recent studies have explored hereditary ferritinopathies, oligogenic genetic interactions, and the clinical implications of exome sequencing in undiagnosed ataxias.

Dr. Keogh’s publications highlight a focus on translational research, including the development of diagnostic tools like the SVI variant interpretation system. His work bridges basic science and clinical applications, contributing to both mechanistic understanding and potential therapeutic avenues in neurodegenerative diseases.