Meng-meng Fu

Meng-meng Fu is an Assistant Professor in Cell Biology, Development and Physiology. Her research focuses on understanding glial cell functions at molecular, cellular, and organismal levels, particularly in the context of myelination and neurodegenerative diseases. Her lab investigates Golgi outpost microtubule nucleation in oligodendrocytes, mRNA transport mechanisms, and cytoskeletal organization in astrocytes. Current projects include studying leukodystrophies and astrocyte cytoskeletal interactions.

Research interests span mechanisms underlying myelination defects, neurodegenerative protein aggregation, and glial cell biology. Recent work explores how genetic mutations in leukodystrophies reveal critical steps in normal myelination and how microglial senescence impacts remyelination. Her lab employs mouse models, biochemical assays, and biophysical techniques to dissect these processes.

Key contributions include identifying TPPP's role in microtubule nucleation for myelination and uncovering the necessity of dynein/dynactin for Mbp mRNA transport. Her publications highlight interdisciplinary approaches bridging cell biology and neurological disease mechanisms.