Ahmet Yildiz

Ahmet Yildiz serves as Professor of Biochemistry, Biophysics and Structural Biology and of Physics at the University of California, Berkeley, leading an active research laboratory in Stanley Hall focused on the biophysical mechanisms of intracellular transport.

Research interests center on motor protein dynamics, particularly dynein and kinesin function along cytoskeletal tracks. The Yildiz Laboratory employs integrated approaches including single-molecule fluorescence imaging, optical trapping, and cryo-electron microscopy to investigate how motors achieve processive movement, generate force in crowded cytoplasmic environments, and are regulated by adaptor proteins and microtubule-associated proteins (MAPs). Key projects examine dynein activation by Lis1/NudE, bidirectional transport reconstitution for mitochondrial cargo, and the "MAP code" hypothesis governing motor recruitment.

Recent publications (2023-2025) demonstrate consistent focus on structural-mechanistic insights into dynein-dynactin complexes and regulatory mechanisms, with emerging connections to neurodegenerative disease pathways through neuronal transport studies. The work bridges quantitative biophysics with cellular physiology through advanced in vitro reconstitution techniques.

The laboratory operates within UC Berkeley's collaborative research ecosystem, utilizing specialized facilities for high-resolution structural biology and single-molecule analysis to advance fundamental understanding of cellular organization principles.