Megan Wright

Dr Megan Wright is an Associate Professor in the School of Chemistry at the University of Leeds, part of the Faculty of Engineering and Physical Sciences. Her research is centered in chemical biology, where she develops and applies innovative chemical tools to study dynamic protein functions and the mechanisms of bioactive small molecules in live cellular environments.

Her research interests span a highly interdisciplinary domain, integrating organic and peptide synthesis, protein biochemistry, cell biology, and quantitative mass spectrometry-based proteomics. Key areas include:

• Target identification of bioactive small molecules in live cells using photo- or chemically-reactive probes with click-compatible tags
• Mapping and imaging protein-protein and protein-ligand interactions, particularly in host-pathogen communication and immune signaling
• Developing chemical tools to study redox regulation of proteins with spatial and temporal resolution across the proteome

Her work addresses critical biological questions in antibacterial resistance, plant growth regulation, and cancer cell signaling pathways by enabling the detection, isolation, and identification of protein interactors in complex biological systems.

Dr Wright collaborates across disciplines to design tools that advance cell biology and deepen understanding of molecular mechanisms. She is based in office G.18b and can be contacted at m.h.wright@leeds.ac.uk.

Scientific Awards:

• No awards listed in the provided text.

Dr Wright advises graduate students and leads an active research group, though specific advisees are not named. There is no mention of external grants or funding sources in the text. She does not appear to be affiliated with a named research lab or center beyond her research group in the School of Chemistry.