Matthieu Ruiz

Dr. Matthieu Ruiz is an Assistant Professor at the University of Montreal, affiliated with the Faculty of Medicine's Department of Nutrition and Department of Pharmacology and Physiology. He is a principal researcher at the Montreal Heart Institute (ICM) and co-director of its metabolomics platform. His work bridges lipid metabolism, cardiovascular disease, and mitochondrial disorders through advanced lipidomics and metabolic flux studies.

• PhD in Cellular and Molecular Pathophysiology (2012) - Université Paris-Sud

Research Focus:
His research explores lipid metabolism disturbances in cardiac and metabolic diseases, including:

• Cardiac manifestations of non-alcoholic fatty liver disease (NAFLD) in obesity
• Metabolic therapy for heart failure using B vitamins
• Mechanisms of lipid dysregulation in French Canadian Leigh Syndrome
• Role of acylcarnitines and plasmalogens in mitochondrial dysfunction
• Sex dimorphism in metabolic responses to cardiac treatments

Article Trends:
His publications reveal a focus on lipidomics, metabolic flux analysis, and translational studies linking lipid metabolism to cardiovascular pathology. Keywords span mass spectrometry applications, biomarker discovery in monogenic disorders, and metabolic profiling across human and murine models.

Scientific Contributions:
Recipient of the 2021 Louise Rousselle Trottier Young Researcher Award and the 2018 William C. Stanley Early Investigator Award.

Academic Leadership:
Supervises graduate students including:

• Baron, Cantin (PhD candidates, 2025)
• Clapatiuc, Valentin (MSc, 2024)
• Burelle, Charlotte (MSc, 2023)

Directs the Lipid Metabolism and Lipidomics Laboratory and co-directs the ICM metabolomics platform. His research is funded by major grants from IRSC, FRQS, and international collaborations like ERA-CVD.