About
Dr. Matthew James Smith is an Associate Professor at the Faculty of Medicine, University of Montreal, leading the Department of Pathology and Cell Biology within the Institute for Research in Immunology and Cancer (IRIC). His lab integrates structural biology, biophysics, and evolutionary bioinformatics to decode RAS GTPase signaling in cancer contexts.
- Research Themes: RAS protein networks, cancer mutations, structural dynamics, and effector validation
- Technologies: NMR spectroscopy, X-ray crystallography, proteomics, and cell-based assays
Recent studies (2025-2024) highlight MRAS as a pseudoinactive GTPase, ARF interactome spatial organization, and RASSF-YAP signaling crosstalk. His work reveals how disease mutations alter signaling hierarchies and binding specificities.
Scientific Recognition:
- Canada Research Chair in Cancer Signaling and Structural Biology
- Recipient of $4M research chair funding (2020)
Contact: matthew.james.smith@umontreal.ca | smithlabiric@gmail.com
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