John Sondek

John Sondek is a Professor in the Department of Biochemistry and Biophysics and Department of Pharmacology at the University of North Carolina at Chapel Hill School of Medicine. He directs the Structural Biology Center and is a member of the Lineberger Comprehensive Cancer Center.

• Structural biology of signal transduction
• Focus on GTPase regulation and signaling cascades

His research explores molecular mechanisms of GTPases and phospholipases in cellular signaling, with implications for cancer and neurodegenerative diseases like Alzheimer's. Recent work emphasizes small molecule activators for PLC-γ2 as potential therapeutics.

Key collaborations involve the Sondek Lab and structural biology initiatives at UNC. His students and colleagues investigate allosteric regulation, G protein mutations, and drug discovery for aberrant signaling pathways.