Matthew Chapman

Matthew Chapman is a Professor and Associate Chair for Graduate Studies in the Department of Molecular, Cellular, and Developmental Biology (MCDB) at the University of Michigan. His research focuses on bacterial amyloid fibers, particularly curli, which are critical for biofilm formation and pathogenesis in enteric bacteria. He investigates the structural, functional, and biogenic mechanisms of curli, exploring their roles in microbial survival, disease, and interactions with human proteins like α-synuclein.

Dr. Chapman earned his Ph.D. from Indiana University (1999) and completed postdoctoral training at Washington University in St. Louis (1999-2003). His work bridges microbiology, biochemistry, and structural biology, employing techniques such as microscopy, genetics, and biochemical assays.

Recent articles highlight advancements in understanding curli’s role in inhibiting amyloid formation, microbial warfare, and neurodegenerative disease connections. The lab’s findings underscore curli’s dual role as both a functional microbial structure and a potential contributor to human pathologies. Collaborative efforts aim to develop anti-biofilm strategies and elucidate amyloid dynamics across kingdoms.

No scientific awards are explicitly listed, though his extensive publication record reflects sustained academic impact. The Chapman Lab actively engages in interdisciplinary research, with projects spanning biofilm engineering and host-pathogen interactions.