Martin Aryee

Dr. Martin Aryee is an Associate Professor of Pathology at Harvard University, affiliated with Massachusetts General Hospital. His research develops computational and statistical methods for analyzing cancer epigenetics and genomic datasets. Key areas include epigenetic mechanisms in human disease, blood-based cancer diagnostics, and genome/epigenome editing for mutation correction.

His

• Statistical modeling of epigenetic variation
• Single-cell RNA sequencing
• CRISPR-Cas9 off-target analysis
• Mitochondrial DNA lineage tracing

research is supported by primary affiliation with the Dana-Farber Cancer Institute (DFCI). Recent publications focus on pancreatic cancer, prostate cancer, and colorectal cancer microenvironment dynamics.

Technical innovations include GUIDE-seq for off-target CRISPR profiling and single-cell mitochondrial genotyping methods. Current projects explore spatial transcriptomics and epigenetic clocks in malignancy. Lab website: https://www.aryeelab.org