Mareike Albert

Mareike Albert is a Professor of Epigenomics of Neural Development at the Faculty of Biology, Center for Regenerative Therapies Dresden (CRTD), TU Dresden. Her research focuses on understanding the epigenetic mechanisms regulating neural stem cells during human neocortex development and evolution, with implications for neurodevelopmental disorders. She leads the Albert Group, which utilizes in vivo models and in vitro human iPSC-derived 3D brain organoids.

• Education: PhD (2008, Friedrich Miescher Institute, Basel), MSc (2003, Curtin University), Diploma (2001, Friedrich Schiller University)
• Positions: Professor (2024-), Research Group Leader (2019-), Staff Scientist (2013-2018, MPI-CBG)

Her work explores neocortex evolution through species-specific gene regulatory elements like ARHGAP11B and NOTCH2NL, differential chromatin dynamics, and the role of epigenetic mis-regulation in neuropathologies. Recent publications investigate EPIREGULIN's role in primate-specific progenitor proliferation and CRISPR/Cas9-based epigenome manipulation.

Research methodologies include:

• Human cortical organoid generation
• CRISPR/Cas9 genome/epigenome editing
• Single-cell epigenomic analysis (Epi-CyTOF)
• Multi-omics profiling (RNA-seq, ChIP-seq, ATAC-seq)