Mark G. Lebwohl

Mark G. Lebwohl, MD, is a Professor and Chairman of the Department of Dermatology at The Icahn School of Medicine at Mount Sinai. Originally trained in internal medicine and cardiology, he transitioned to dermatology after discovering a novel association between pseudoxanthoma elasticum (PXE) and mitral valve prolapse during his residency. His pioneering research on PXE, published in the New England Journal of Medicine, laid the foundation for identifying the genetic defect responsible for this rare disorder. With federal grants supporting his work, Dr. Lebwohl leads efforts to develop treatments to prevent PXE-related complications such as cardiovascular disease and blindness.

• Role: Chairman and Professor of Dermatology
• Specialization: Complex skin diseases, surgical dermatology, and PXE research
• Institutional Impact: Expanded Mount Sinai's Dermatology Department from a small unit to the largest in the U.S., with 300 faculty and robust research divisions

His research bridges internal medicine and dermatology, focusing on the systemic manifestations of cutaneous genetic disorders. Dr. Lebwohl's leadership has established Mount Sinai as a top-ranked dermatology department with strengths in clinical research, dermatopathology, and noninvasive imaging.

While specific scientific awards are not detailed in the text, his work has been supported by federal grants and has significantly advanced understanding of PXE. Dr. Lebwohl's educational background includes Harvard Medical School and Mount Sinai training.