Manuela Neumann

Manuela Neumann is a Professor and Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Tübingen, Germany, researching molecular mechanisms of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) with emphasis on TDP-43 and FUS protein aggregation.

Her primary research spans neurodegenerative diseases, ALS, FTLD, molecular neuroscience, protein aggregation, and RNA metabolism. The Neumann group investigates physiological functions of TDP-43, FUS, and C9orf72 proteins in the central nervous system, mechanisms of neurodegeneration (loss of function vs. toxic gain of function), and molecular classification of disease subtypes to advance therapeutic development.

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The laboratory employs advanced methodologies including histological/proteomic analysis, image processing, antibody generation, primary neuron cultures, organotypic slice cultures, and genetically modified mouse models (knock-out, knock-in, overexpression). Current projects focus on TDP-43/FUS posttranslational modifications, disease-model development, transcriptomic/epigenetic/proteomic changes, and C9orf72-TDP-43 interactions using human brain bank tissues.