Manuela Neumann

Prof. Dr. Manuela Neumann is a group leader at the German Center for Neurodegenerative Diseases (DZNE) and affiliated with the University of Tübingen. Her research focuses on the molecular mechanisms of neurodegenerative diseases, particularly frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), where she investigates protein aggregates like TDP-43 and FUS.

• Institution: German Center for Neurodegenerative Diseases (DZNE), University of Tübingen
• Role: Group Leader, Researcher
• Contact: manuela.neumann@dzne.de

Her work centers on understanding the physiological roles of TDP-43, FUS, and C9orf72 proteins in the central nervous system, distinguishing between loss-of-function and toxic gain-of-function mechanisms in ALS/FTLD pathogenesis. She employs advanced methodologies such as genetically modified mouse models, proteomics, and primary cell cultures to identify molecular similarities across diseases.