Manon Mirgaux

Manon Mirgaux is an active researcher at the University of Namur specializing in structural biology and computational biochemistry, with significant contributions to understanding enzyme mechanisms particularly in the kynurenine pathway. Her work bridges crystallography, molecular dynamics, and drug design for cancer immunotherapy applications.

Her research focuses on the structural and dynamic properties of enzymes including indoleamine 2,3-dioxygenases (IDO1/IDO2) and phosphoserine phosphatase. Through combined crystallographic and computational approaches, she investigates enzyme mechanisms, cofactor interactions, and substrate binding to develop novel inhibitors for therapeutic applications, particularly in cancer immunotherapy.

Mirgaux's publication record demonstrates consistent output in high-impact structural biology journals, with recent work (2020-2024) examining IDO enzyme dynamics, chalcogen bonding in drug design, and Mycobacterium tuberculosis transcription factors. Her research shows strong methodological integration of X-ray crystallography, molecular dynamics simulations, and biochemical analysis.

• Mechanistic study of the human phosphoserine phosphatase (hPSP): crystallographic and computational approaches (10 Oct 2019)
• Mechanistic study of the human phosphoserine phosphatase (hPSP): crystallographic and computational approaches (15 Nov 2019)
• Young Medicinal Chemist Award in Belgium (SRC) (19 May 2022)

Mirgaux has led two significant research projects: 'Cancer immunotherapy and dual IDO/TDO inhibitors' (2019-2021) and 'Towards the design of innovating inhibitors for the first step of the kynurenine pathway' (2021-2023), both supervised by Professor Wouters. She actively participates in major conferences including the European Crystallography Meeting and FNRS Med Chem Symposium, demonstrating strong integration in the structural biology and medicinal chemistry communities.