Mahmoud Ghannoum

Mahmoud Ghannoum, PhD, is a Professor in the Departments of Dermatology and Pathology at Case Western Reserve University School of Medicine, and Director of the Center for Medical Mycology at University Hospitals. His research focuses on fungal pathogens (e.g., Candida, Aspergillus, Cryptococcus) and their virulence factors, including biofilm formation and adhesion. He investigates the role of the bacteriome and mycobiome in cancer and inflammatory diseases like Crohn’s, emphasizing polymicrobial biofilms as potential drivers of colorectal cancer and gastrointestinal disorders.

Dr. Ghannoum’s work spans microbial interactions, probiotic development for inflammation resolution, and antifungal resistance. He leads the Molecular Oncology Program at the Case Comprehensive Cancer Center, integrating microbiome research with oncology. His external roles include directing the Center for Medical Mycology, addressing fungal infections globally.

• Education: Advanced training in Medical Mycology.
• Research Interests: Fungal pathogenesis, microbiome-cancer interactions, probiotics, and antifungal therapies.

Publications highlight his contributions to understanding fungal virulence, antimicrobial stewardship, and novel treatments for infections like onychomycosis and vulvovaginal candidiasis. His lab also explores microbiome modulation in chronic diseases, including autism and neuroendocrine tumors.

Notable collaborations include studies on antibiotic resistance, gut-brain axis links, and probiotic formulations for inflammatory bowel disease. His research frequently addresses translational applications, bridging basic science and clinical practice.