Lindsay R. Comstock-Ferguson

Lindsay R. Comstock-Ferguson is an Associate Professor in the Department of Chemistry at Wake Forest University. She holds a B.S. from Northern Arizona University (2000), a Ph.D. in Pharmaceutical Sciences from the University of Wisconsin-Madison (200X), and completed a postdoctoral fellowship in Biomolecular Chemistry there under J.M. Denu. Her research focuses on the chemistry-biology interface, particularly the role of post-translational modifications in cellular processes and disease. She develops small-molecule tools to study methyltransferases and kinases, using cofactor mimics to investigate modifications in vivo.

Key areas of interest include S-adenosyl-L-methionine analogs, ribosomal RNA modifications, and epigenetic regulation. Her work bridges organic chemistry, biochemistry, and molecular biology to understand disease mechanisms and develop biochemical probes. No awards are explicitly listed in the provided materials.

Her lab’s research emphasizes understanding chemical driving forces behind biologically important processes through post-translational modifications. Collaborations with Dunham and Conn on ribosomal modification (e.g., RmtC and TlyA) highlight her focus on antibiotic resistance and bacterial pathogenesis. Early work includes DNA labeling strategies and enzymatic cleavage mechanisms.