Laura R. McCabe

Laura R. McCabe is a Professor at Michigan State University (MSU), holding dual appointments in the Department of Physiology (College of Natural Science) and the Department of Radiology (College of Human Medicine). Her research focuses on endocrine disruption and bone physiology, particularly through the lens of gut-bone signaling.

• Education:
  • B.S. in Biology, University of Chicago (1986)
  • Ph.D. in Biological Science, University of Chicago (1991)

McCabe's work investigates mechanisms of bone loss in conditions like type 1 diabetes, glucocorticoid use, estrogen-deficiency, and inflammatory bowel disease, all linked to gut microbiota dysbiosis. Her lab has demonstrated that probiotics can enhance bone density in mice and prevent bone loss, positioning the gut as a therapeutic target for osteoporosis. Key methodologies include mouse models, microbiome analysis, and metabolomics.

Recent publications highlight her team's focus on gut-bone signaling (2017-2020), with studies on probiotics, lymphocyte dependence, and inflammatory pathways. Collaborations span microbiome research, mathematical modeling, and immune system contributions.

Scientific Awards:

• MSU Foundation Professor

Labs & Teams:
The lab integrates scientists studying microbiome, metabolomics, bone signaling, and immune contributions to unravel gut-bone axis mechanisms.